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Exploratory Study of T Cell Skin Trafficking and the Role of NKG2D Signaling; Implications in Vitiligo and Melanoma

Award Number: R21AR081633
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/18/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Exploratory Study of T Cell Skin Trafficking and the Role of NKG2D Signaling; Implications in Vitiligo and Melanoma - Abstract In the field of immunology, T cell migration is considered crucial for long-term host survival. However, the identity of the players that participate and the mechanistic relationships in this complex network remain to be fully established, especially in the context of vitiligo and melanoma. Our understanding of the T cell migratory properties and initiation ques may help find clinically applicable treatments to vitiligo and melanoma. Based on novel preliminary data, we propose to study NKG2D signaling as a contributor to T cell trafficking. The scientific premise of this study is derived from our work demonstrating that lack of NKG2D reduces T cell tmigration and expression of CCR4. We hypothesize that NKG2D controls CD8 T cell trafficking through a finely tuned DAP10PI3K/Grb2 signaling (as NKG2D cannot signal by itself instead of using DAP10PI3K/Grb2 as signaling adaptor) that controls the expression of CCR4. This proposal will define the underlying roles of NKG2D-DAP10PI3K and -DAP10Grb2 in CD8 T cell trafficking and the expression control of CCR4. Here we will conduct experimental tests utilizing human and mouse models. SA1. TO DETERMINE THE SIGNALING PATH FOR NKG2D-DAP10PI3K and/or -DAP10Grb2 THAT CONTROLS CCR4 EXPRESSION. SA2. TO DETERMINE THE SPECIFIC CONTRIBUTION OF NKG2D-DAP10PI3K and/or -DAP10Grb2 SIGNALING IN THE SKIN TRAFFIC OF CD8 T CELLS.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	12/11/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $407,770 )
2023	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/18/2023	NEW	$407,770
														Subtotal = $407,770

Grand Total All Awards = $407,770

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Exploratory Study of T Cell Skin Trafficking and the Role of NKG2D Signaling; Implications in Vitiligo and Melanoma

Award Number: R21AR081633

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/18/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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