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A Hydrogel Ionic Circuit-Based Electrical Stimulation System for Restoration of Denervated Muscles After Peripheral Nerve Injuries

Award Number: R21AR078439
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary: Muscle electrical stimulation (EStim) is a promising rehabilitation modality for denervated muscles after peripheral nerve injuries. Current muscle EStim devices have limited therapeutic efficacy due to the low EStim intensity they apply. Applying high-intensity EStim to muscles presents a significant challenge. This is because all current devices conduct electron currents. Electrochemical reactions are required to convert the electron currents to the ion currents at the device-tissue interface. These reactions can induce chemical changes and temperature increase that can damage tissues when the EStim intensity is high. Thus, there is a critical need for a new generation of muscle stimulators that can safely apply high-intensity EStim for efficacious preservation of denervated human muscles. The long-term goal is to develop efficacious EStim-based therapy to preserve denervated human muscles after peripheral nerve injuries. The overall objectives of this proposal is to develop a novel EStim device that can safely apply high-intensity EStim to improve the preservation of denervated muscles. In Specific Aim 1, we will determine the optimal EStim device design for safe application of high-intensity EStim. Our working hypothesis is that a wirelessly coupled, ion current-conducting hydrogel ionic circuit (HIC) device does not induce any electrochemical reactions, so it can minimize adverse effects when applying high-intensity EStim. In Specific Aim 2, we will determine the efficacy of high-intensity EStim applied by our device for the preservation of denervated muscles using a pre-clinical rat peripheral nerve injury model. Our working hypothesis is that high- intensity EStim can improve muscle preservation compared to the low-intensity EStim typically used in current studies. The sensory recovery, motor recovery and muscle quality will be evaluated. The rationale for this project is that the development of a wirelessly coupled, completely ion current-based stimulator will significantly increase the EStim intensity that can be applied without causing tissue damage. This will lead to improved muscle rehabilitation outcomes following peripheral nerve injury that is not possible with current stimulators. Our outcome will establish an optimal device design to enable safe and efficient high- intensity EStim application. We will also demonstrate the in vivo efficacy of high-intensity EStim protocol for muscle preservation. Our high impact project will provide a strong justification for further development and testing of our device for treating denervated human muscles following peripheral nerve injuries. This will ultimately lead to better rehabilitation outcomes and improved quality of life for patients suffering from peripheral nerve injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$9,979 )
2025	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	11/4/2024	NON-COMPETING CONTINUATION	-$9,979
														Subtotal = -$9,979

Issue Date FY: 2022 ( Subtotal = $199,787 )
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	6/28/2022	NON-COMPETING CONTINUATION	$199,787
														Subtotal = $199,787

Issue Date FY: 2021 ( Subtotal = $178,307 )
2021	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/6/2021	NEW	$178,307
														Subtotal = $178,307

Grand Total All Awards = $368,115

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A Hydrogel Ionic Circuit-Based Electrical Stimulation System for Restoration of Denervated Muscles After Peripheral Nerve Injuries

Award Number: R21AR078439

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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