Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Development and validation of lens-free polarized microscopy to identify mono-sodium urate and calcium pyrophosphate crystals from synovial fluid

Award Number: R21AR072946
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/09/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2021

Group Awards By:

View Award Description

Development and validation of lens-free polarized microscopy to identify mono-sodium urate and calcium pyrophosphate crystals from synovial fluid - ABSTRACT Crystal arthropathy is the most common type of inflammatory arthritis, caused by the deposition of either monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPP) crystals in or around joints, clinically recognized as either gout or pseudogout. Diagnosis of crystal arthropathy can be established by identifying MSU or CPPD crystals in the synovial fluid with a compensated polarized light microscope (CPLM). CPLM has been the gold- standard diagnostic instrument for crystal arthropathy since 1961. However, given the limited field of view (FOV) of CPLM, examination for crystals can be laborious. Furthermore, the sensitivity of CPLM can be affected by crystal concentration, size, and birefringent properties (particularly for CPP crystals), as well as technician experience. There exists the need to develop an inexpensive high-resolution, wide-FOV polarized microscopic device for synovial fluid screening, with improved sensitivity. Lens-free on-chip microscopy has developed in the past decade. The advantages of the lens-free microscope include high-resolution, wide FOV, low cost and compact instrumentation. However, lens-free technology has not been adapted to perform polarized imaging due to a fundamental difference in its imaging principle. We have developed a way to overcome this challenge and have preliminary data showing the ability of our system to accurately detect both MSU and CPP crystals. The proposed lens-free polarized on-chip microscope will enable the rapid screening and sensitive detection of birefringent crystals in synovial fluid samples of patients, greatly improving the sensitivity and efficiency of gout and pseudogout diagnosis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$174 )
2022	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	10/21/2021	NON-COMPETING CONTINUATION	-$174
														Subtotal = -$174

Issue Date FY: 2019 ( Subtotal = $171,600 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	5/17/2019	NON-COMPETING CONTINUATION	$171,600
														Subtotal = $171,600

Issue Date FY: 2018 ( Subtotal = $203,120 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	8/9/2018	NEW	$203,120
														Subtotal = $203,120

Grand Total All Awards = $374,546

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Development and validation of lens-free polarized microscopy to identify mono-sodium urate and calcium pyrophosphate crystals from synovial fluid

Award Number: R21AR072946

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/09/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2021

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer