Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Development and application of pediatric-specific blood transcriptional modules across diverse geographical settings through public data mining

Award Number: R21AI191085
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/25/2025
PERIOD OF PERFORMANCE END DATE: 01/31/2027

Group Awards By:

View Award Description

Development and application of pediatric-specific blood transcriptional modules across diverse geographical settings through public data mining - Project Summary/Abstract Blood transcriptional modules (BTMs), consisting of functionally related gene sets developed through dimensional reduction computational methods, have emerged as a significant tool for the biological interpretation of bulk transcriptomic data. However, current BTMs, primarily derived from North American and European adult data, fail to capture the immunological characteristics of pediatric populations across diverse geographical settings. To address this significant gap, we aim to develop pediatric-specific BTMs (pBTMs) that capture the broad range of heterogeneous physiological states during childhood and include underrepresented pediatric geographical cohorts through public data mining. For this purpose, we will construct modules utilizing transcriptome data from children aged birth to 12 years. We have gathered 13,388 samples from 76 studies across various physiological conditions, enabling the construction of robust and widely applicable pediatric- specific modules. This work will be the first to establish pediatric-specific BTMs, serving as a valuable resource for pediatric immunology research and empowering the development of vaccines and therapies to reduce the burden of infections and other immune-mediated diseases in childhood. This project also aims to address several limitations of previous frameworks by incorporating an improved a priori knowledge base using pediatric single- cell datasets and an assessment framework for the biological relevance of the pBTMs using genome-wide association studies (GWAS). Our state-of-the-art and novel computational framework will be delivered as a portable, version-controlled, publicly available pipeline that can be replicated in other disease and tissue type settings. To demonstrate the utility of pBTMs and as a proof of concept, we will utilize these modules to define immunological differences across geographically disparate pediatric populations, informing research into variability in childhood immune responses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $160,264 )
2026	2026	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	2	4/1/2026	NON-COMPETING CONTINUATION	$160,264
														Subtotal = $160,264

Issue Date FY: 2025 ( Subtotal = $286,791 )
2025	2025	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	1	2/25/2025	NEW	$286,791
														Subtotal = $286,791

Grand Total All Awards = $447,055

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Development and application of pediatric-specific blood transcriptional modules across diverse geographical settings through public data mining

Award Number: R21AI191085

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/25/2025

PERIOD OF PERFORMANCE END DATE: 01/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer