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Overcoming obstacles in structural elucidation of B cell antigen receptor assembly and lateral interaction

Award Number: R21AI188071
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/09/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Overcoming obstacles in structural elucidation of B cell antigen receptor assembly and lateral interaction - Abstract Development of effective adaptive immunity following infection and vaccination requires recognition of antigens and secretion of antibodies by B cells. T and B cells are the two major types of lymphocytes in the immune system. T cells can sense MHC-bound antigens by the T cell receptors (TCRs) and B cells can recognize free, unprocessed antigens by the B cell receptors (BCRs). Despite the critical importance of BCRs, how BCRs are assembled and regulated remain unclear. In this application, we propose to overcome certain technical obstacles in our pursuit of BCR assembly and regulation by engineering appropriate cell lines and using the native membrane environment for complex formation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $489,500 )
2025	2025	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	1	7/9/2025	NEW	$489,500
														Subtotal = $489,500

Grand Total All Awards = $489,500

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Overcoming obstacles in structural elucidation of B cell antigen receptor assembly and lateral interaction

Award Number: R21AI188071

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/09/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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