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Use of allogeneic pMHCII-based 5MCAR-CTLs to eliminate alloreactive lymphocytes in transplant

Award Number: R21AI183310
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY The immune system is a significant barrier to successful clinical organ transplantation, requiring life-long immunosuppression to prevent allograft rejection. Current immunosuppressive strategies rely primarily on broad pharmacologic inhibition of lymphocyte function. This approach is limited by susceptibility to breakthrough immune responses causing acute rejection episodes, with simultaneous unwanted impairment of protective immune responses against infection and tumors. Thus, new approaches for specific and durable allograft- specific immunosuppression are critically needed. We propose to utilize a pMHCII-based allogeneic 5-module chimeric antigen receptor-cytotoxic T cell (5MCAR-CTL) system to target and eliminate alloreactive CD4+ T cells. These investigations represent a conceptual advance in proposing to utilize cutting-edge cellular engineering with 5MCAR technology to develop a novel approach aimed at specific and durable immunosuppression in transplantation. Successful completion of the proposed experiments will generate tools and data to support refinement and development of this clinically-translatable cell engineering approach.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $188,775 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	3/15/2024	NEW	$188,775
														Subtotal = $188,775

Grand Total All Awards = $188,775

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Use of allogeneic pMHCII-based 5MCAR-CTLs to eliminate alloreactive lymphocytes in transplant

Award Number: R21AI183310

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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