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Indirect Prevention of High Path Flu Zoonosis through Universal Vaccination

Award Number: R21AI180686
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/25/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Indirect Prevention of High Path Flu Zoonosis through Universal Vaccination - PROJECT SUMMARY / ABSTRACT Highly pathogenic and low pathogenic strains of avian influenza continue to circulate and infect birds in Asia with occa- sional spread into the North American flyway. These necessitate the culling of any poultry farms that test positive for these strains. Furthermore, through continued circulation, humans remain under constant threat that one of these strains will reassort and infect humans. While the current strategy for combating these strains is surveillance and biosecurity, these strategies clearly do not work in many parts of the world, as they are hot zones for these viruses. As an alternative, vaccinations for poultry and waterfowl would certainly be a boon for human health as they would restrict the number of influenza strains in these flu reservoirs. Here, we seek to use mRNA vaccines that code for a universal flu Hemagglutinin antigen we have developed. In tandem with polyanhydride delivery vehicles that impart thermostability to mRNA and serve as antigen depots, we will vaccinate chicken eggs to determine efficacy against highly pathogenic and low patho- genic avian influenza strains. We will also develop transgenic mealworms to use as booster or as primary vaccines for poultry, but eventually waterfowl, for future use as flu vaccine bait stations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY	1350 BEARDSHEAR HALL	AMES	IA	50011	STORY	USA	Allergy and Infectious Diseases Research	000	2	2/5/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $186,946 )
2025	2025	IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY	1350 BEARDSHEAR HALL	AMES	IA	50011	STORY	USA	Allergy and Infectious Diseases Research	000	2	4/17/2025	NON-COMPETING CONTINUATION	$186,946
														Subtotal = $186,946

Issue Date FY: 2024 ( Subtotal = $225,370 )
2024	2024	IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY	1350 BEARDSHEAR HALL	AMES	IA	50011	STORY	USA	Allergy and Infectious Diseases Research	001	1	9/12/2024	NEW	$22,537
2024	2024	IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY	1350 BEARDSHEAR HALL	AMES	IA	50011	STORY	USA	Allergy and Infectious Diseases Research	000	1	6/25/2024	NEW	$202,833
														Subtotal = $225,370

Grand Total All Awards = $412,316

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Indirect Prevention of High Path Flu Zoonosis through Universal Vaccination

Award Number: R21AI180686

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/25/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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