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Elucidation of the interactome for the bioactive disaccharide Man(B1-4)GlcNAc

Award Number: R21AI178437
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/08/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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Elucidation of the interactome for the bioactive disaccharide Man(B1-4)GlcNAc - PROJECT SUMMARY Some autoimmune diseases, including systemic lupus erythematosus or “lupus,” are now known to occur because of the pathogenic excess of an intracellular disaccharide called Man(b1- 4)GlcNAc. The accumulation of this disaccharide in cells can lead to the erroneous activation of immune responses, leading to autoimmunity. The molecular mechanisms through which Man(b1- 4)GlcNAc regulate autoimmunity remain unknown, due to the difficulties of capturing the intracellular interactors and receptors of free oligosaccharides, like Man(b1-4)GlcNAc. We will use a chemoproteomic mass spectrometry-based approach to elucidate the interactome of Man(b1-4)GlcNAc to identify its functional receptors. The accomplishments resulting from this work will result in an enhanced understanding of aberrant glycosylation and the bioactivity of free Man(b1-4)GlcNAc, as well as pave the pathway for studying the interactomes of intracellular free oligosaccharides.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $223,100 )
2025	2025	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	2	11/19/2024	NON-COMPETING CONTINUATION	$223,100
														Subtotal = $223,100

Issue Date FY: 2024 ( Subtotal = $271,500 )
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	1	9/11/2024	NEW	$27,150
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	1/8/2024	NEW	$244,350
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	1	9/4/2024	NEW	$0
														Subtotal = $271,500

Grand Total All Awards = $494,600

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Elucidation of the interactome for the bioactive disaccharide Man(B1-4)GlcNAc

Award Number: R21AI178437

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/08/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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