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Characterization of TCS11 in Streptococcus pneumoniae

Award Number: R21AI178084
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Characterization of TCS11 in Streptococcus pneumoniae - Summary A fundamental aspect of the success of Streptococcus pneumoniae as a human pathogen is the ability to successfully transmit and infect new hosts. The mechanisms underlying transmission are complex, with both bacterial and host factors playing important roles. It would be expected the capacity is sense and response to the dynamic environment of the mammalian host is critical for transmission, however the regulation underscoring this process remains poorly understood. We hypothesize transmission is controlled via a specific, uncharacterized two- component regulatory system (TCS11). This TCS has atypical operon structure for pneumococcal TCSs, whereby two small hypothetical proteins and a putative transporter are in the same operon and co-transcribed with TCS11. Preliminary data suggests is this operon is in fact a TCS coupled to a bacteriocin secretion system that facilitates transmission via targeting the resident bacterial flora, enabling pneumococcal transmission. We hypothesize that TCS11 mediates pneumococcal transmission via coordination of transmission factor gene expression coupled with bacteriocin production to effectively compete against the respiratory microbiota at the initial stages of epithelial colonization.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $220,675 )
2025	2025	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Allergy and Infectious Diseases Research	000	2	12/9/2024	NON-COMPETING CONTINUATION	$220,675
														Subtotal = $220,675

Issue Date FY: 2024 ( Subtotal = $273,000 )
2024	2024	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Allergy and Infectious Diseases Research	001	1	9/12/2024	NEW	$27,300
2024	2024	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Allergy and Infectious Diseases Research	000	1	1/30/2024	NEW	$245,700
														Subtotal = $273,000

Grand Total All Awards = $493,675

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Characterization of TCS11 in Streptococcus pneumoniae

Award Number: R21AI178084

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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