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Haplotype-resolved genome assemblies and chromosomal rearrangements in arboviral vector Aedes albopictus

Award Number: R21AI174052
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY The Asian tiger mosquito Aedes albopictus is native to Southeast Asia but in a few decades this species expanded its range to all continents except Antarctica. Aedes albopictus is capable of transmitting multiple arboviruses including dengue—the leading arboviral disease of 21st century—Chikungunya, and Zika—an emerging health threats for the world. Because of its remarkable ability to develop a photoperiodic diapause in the temperate climate, Ae. albopictus has the potential to spread these dangerous diseases further north. This project will develop haplotype-resolved chromosome-scale genome assemblies for multiple strains of Ae. albopictus and will test if adaptations to the temperate climate are associated with chromosomal rearrangements in this mosquito. Toward this end, we propose the following specific aims: 1) develop a haplotype-resolved chromosome-scale genome assemblies for four strains of Ae. albopictus including the Foshan strain; 2) improve the physical genome map for the Foshan strain of Ae. albopictus; and 3) identify chromosomal rearrangements in different populations of Ae. albopictus world-wide. Our long- term goal is to understand the genetic basis of the incredible phenotypic plasticity of Ae. albopictus that helps this mosquito to rapidly spread around the globe. We envision that the availability of the high-quality reference genome assemblies for multiple strains of Ae. albopictus will stimulate further genetic studies aimed at preventing mosquito-borne disease transmission.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $187,903 )
2024	2024	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW	BLACKSBURG	VA	24060	MONTGOMERY	USA	Allergy and Infectious Diseases Research	001	2	5/9/2024	NON-COMPETING CONTINUATION	$18,790
2024	2024	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW	BLACKSBURG	VA	24060	MONTGOMERY	USA	Allergy and Infectious Diseases Research	000	2	10/25/2023	NON-COMPETING CONTINUATION	$169,113
														Subtotal = $187,903

Issue Date FY: 2023 ( Subtotal = $227,056 )
2023	2023	VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY	300 TURNER ST NW	BLACKSBURG	VA	24060	MONTGOMERY	USA	Allergy and Infectious Diseases Research	000	1	11/8/2022	NEW	$227,056
														Subtotal = $227,056

Grand Total All Awards = $414,959

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Haplotype-resolved genome assemblies and chromosomal rearrangements in arboviral vector Aedes albopictus

Award Number: R21AI174052

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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