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Characterizing new nematode-specific drug targets to eliminate the reservoir for human toxocariasis

Award Number: R21AI144493
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Toxocara canis causes visceral and ocular larval migrans in humans. The reason why this disease cannot be eliminated is because tissue-dwelling larvae persist in the animal reservoir (dogs) where they tolerate anthelmintic treatment, and the mechanism for drug tolerance is unknown. Our hypothesis is that T. canis larvae evade drug treatment by effluxing antiparasitic drugs with permeability glycoproteins (P- glycoproteins) that efflux anthelmintics. In this application we propose to 1) record the repertoire of P- glycoprotein gene expression in T. canis, 2) map the precise tissues where P-glycoproteins are expressed, 3) demonstrate induction of P-glycoprotein activity by anthelmintic drugs, 4) characterize the unique pharmacology of T. canis P-glycoprotein, and 5) discover nematode-specific P-glycoprotein inhibitors that enhance the performance of antiparasitic drugs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY	1350 BEARDSHEAR HALL	AMES	IA	50011	STORY	USA	Allergy and Infectious Diseases Research	000	2	10/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $191,250 )
2020	2020	IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY	515 MORRILL RD, 1350 BEARDSHEAR HALL	AMES	IA	50011	STORY	USA	Allergy and Infectious Diseases Research	000	2	1/30/2020	NON-COMPETING CONTINUATION	$191,250
														Subtotal = $191,250

Issue Date FY: 2019 ( Subtotal = $191,250 )
2019	2019	IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY	1350 BEARDSHEAR HALL	AMES	IA	50011	STORY	USA	Allergy and Infectious Diseases Research	000	1	2/28/2019	NEW	$191,250
														Subtotal = $191,250

Grand Total All Awards = $382,500

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Characterizing new nematode-specific drug targets to eliminate the reservoir for human toxocariasis

Award Number: R21AI144493

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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