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The Aspergillus fumigatus Genetic Variant and Isolate Repository (FumigatusGVIR): A community resource to facilitate association mapping of pathogenicity associated traits

Award Number: R21AI137485
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Nearly 600 fungal species are capable of causing human infections, affecting ~300 million people worldwide. Though most fungal infections are non-life threatening, mortality rates from several species can exceed 50%. Aspergillus fumigatus is the most prominent opportunistic fungal pathogen and is responsible for the deaths of ~100,000 people annually. Over the last several decades, a tremendous collection of work has been devoted to uncovering the mechanisms, molecules, and genes involved in A. fumigatus pathogenicity. Despite these efforts, treating and controlling A. fumigatus infections is more challenging than ever, largely due to the emergence of drug resistance and the increased usage of immunosuppressive treatments. New resources, tools, and approaches are needed to decipher the genes and polymorphisms underlying the complex nature of A. fumigatus pathogenicity. To date, A. fumigatus genomic research has lagged behind the pace at which DNA-sequencing technologies and computational biology methodologies have advanced. The ultimate goal of this proposal is to establish a community resource of A. fumigatus isolates and their associated genetic variant data in an effort to facilitate quantitative genetic and population genomic research. In Aim 1, we will create a publicly available collection of 230 genetically and phenotypically diverse A. fumigatus isolates that will be used as a reference panel for trait measurements. In Aim 2, we will sequence the genomes of each isolate and comprehensively catalogue genetic variation for use in A. fumigatus association mapping. In Aim 3, we will conduct a proof-of- concept genome-wide association analysis of virulence in the well-established wax moth larvae model system of invasive aspergillosis. At the conclusion of these studies we will have (i) created an invaluable tool that will allow for rapid, economical, and reliable association mapping of pathogenicity-associated traits, (ii) applied novel approaches to address and expand our knowledge of the genetic basis of A. fumigatus pathogenicity, and (iii) identified novel candidate genes to functionally examine in future studies. The results of this proposal have the potential to positively impact the hundreds of thousands of people burdened by A. fumigatus infection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$23,298 )
2023	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Allergy and Infectious Diseases Research	000	3	10/11/2022	NON-COMPETING CONTINUATION	-$23,298
														Subtotal = -$23,298

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Allergy and Infectious Diseases Research	003	3	4/7/2022	NON-COMPETING CONTINUATION	$23,297
2022	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Allergy and Infectious Diseases Research	002	3	4/5/2022	NON-COMPETING CONTINUATION	-$23,297
2022	2018	TRUSTEES OF CLARK UNIVERSITY	950 MAIN ST	WORCESTER	MA	01610	WORCESTER	USA	Allergy and Infectious Diseases Research	000	1	4/4/2022	NEW	$0
2022	2018	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Allergy and Infectious Diseases Research	001	2	4/4/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Allergy and Infectious Diseases Research	000	3	2/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $204,188 )
2019	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Allergy and Infectious Diseases Research	003	3	1/17/2019	NON-COMPETING CONTINUATION	$195,515
2019	2018	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Allergy and Infectious Diseases Research	001	2	11/16/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$198,974
2019	2018	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Allergy and Infectious Diseases Research	002	2	12/31/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2019	2018	TRUSTEES OF CLARK UNIVERSITY	950 MAIN ST	WORCESTER	MA	01610	WORCESTER	USA	Allergy and Infectious Diseases Research	000	1	11/15/2018	NEW	-$190,301
														Subtotal = $204,188

Issue Date FY: 2018 ( Subtotal = $225,450 )
2018	2018	TRUSTEES OF CLARK UNIVERSITY	950 MAIN ST	WORCESTER	MA	01610	WORCESTER	USA	Allergy and Infectious Diseases Research	000	1	1/25/2018	NEW	$225,450
														Subtotal = $225,450

Grand Total All Awards = $406,340

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The Aspergillus fumigatus Genetic Variant and Isolate Repository (FumigatusGVIR): A community resource to facilitate association mapping of pathogenicity associated traits

Award Number: R21AI137485

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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