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Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women

Award Number: R21AG101515
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women - PROJECT SUMMARY/ABSTRACT Vasomotor symptoms (hot flashes) associated with menopause consist of rapid and intense sweating, peripheral vasodilation, and an exaggerated feeling of internal heat. Over 70% of women experience hot flashes at some point during menopause, which significantly impacts day to day life. Furthermore, hot flash frequency is related to increased risk of hypertension, cardiovascular disease (CVD), sleep, and mood disorders--even when controlling for traditional cardiovascular disease risk factors (obesity, hypertension, lipids, etc.). For the purposes of this application, we will define neurovascular function as a concept that encompasses sympathetic outflow, the responses of blood vessels to neurotransmitters released by the sympathetic nerves and the intrinsic properties of the vascular endothelium and smooth muscle. In this context, neurovascular function is critically important to women’s health and aging. Neurovascular function, including elevated sympathetic control of blood pressure, has been implicated the positive relationship between hot flashes and cardiovascular disease. Further, nocturnal awakenings during hot flashes are associated with increases in sympathetic activity. As such, the overall goal of this application is to assess the impact of a high-resistance inspiratory strength muscle on sympathetic nerve activity and sleep in postmenopausal females with hot flashes. Aim 1 will determine if 6 weeks of high-resistance inspiratory muscle strength training reduces sympathetic nerve activity in postmenopausal females with hot flashes. Aim 2 will establish whether 6 weeks of high-resistance inspiratory muscle strength training will improve sleep through reductions in nocturnal awakenings due to reduced hot flash frequency in postmenopausal females with hot flashes. Importantly, this work will provide objective mechanistic evaluation of autonomic and neurovascular function in midlife women including those undergoing menopause. Understanding how the neurovascular physiology of women relates to hot flashes will inform hypertension and cardiovascular disease (CVD) treatment and prevention options, as the presence of hot flashes are a CVD risk factor beyond traditional CVD risk factors and as such, is likely to be an important determinant for a woman’s health. Thus, these studies will begin working toward the Applicant’s long-term goal of developing interventions to reduce the incidence of cardiovascular disease in women with hot flashes. Finally, this work will provide pilot data that complement the Applicant’s intellectual and technical skills for future work to improve cardiovascular health in women with menopausal hot flashes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $439,258 )
2026	2026	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Aging Research	000	1	6/16/2026	NEW	$439,258
														Subtotal = $439,258

Grand Total All Awards = $439,258

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Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women

Award Number: R21AG101515

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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