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Lifespan extension, Somatotropic signaling and Tauopathy

Award Number: R21AG082327
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2023
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Lifespan extension, Somatotropic signaling and Tauopathy - Tauopathies are a class of neurodegenerative diseases characterized by accumulation of abnormal and hyperphosphorylated tau protein in the brain including Alzheimer's disease (AD), Parkinson's disease (PD), Frontotemporal dementia (FTD), and Motor Neuron Disease (MND). Tauopathies occur primarily in elderly population and incidence rises with increasing age. Unfortunately, the mechanisms for the age-dependent onset of tauopathies are unknown and there are no effective therapeutic strategy. Aging is the biggest risk factor for tauopathies related disorders, suggesting that molecular alterations contributing to the aging process may represent common mechanisms for tau pathology. Employing the pathways that could slow or delay the aging process may offer novel targets for new therapeutic strategies. Murine mutant mice with slow rates of aging and murine tauopathy models with varying phenotypic effects provide the opportunity to develop novel genetic models that will allow studying the interaction of aging and tauopathy. Our proposal is to elucidate the role of the somatotropic axis in the age-dependent susceptibility to tauopathies. Our study will generate new models to study the interaction of aging with neurodegenerative diseases in the context of mutations that slow the aging process.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $185,625 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	2	3/4/2024	NON-COMPETING CONTINUATION	$167,063
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	2	6/28/2024	NON-COMPETING CONTINUATION	$18,562
														Subtotal = $185,625

Issue Date FY: 2023 ( Subtotal = $222,750 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	1	5/11/2023	NEW	$222,750
														Subtotal = $222,750

Grand Total All Awards = $408,375

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Lifespan extension, Somatotropic signaling and Tauopathy

Award Number: R21AG082327

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2023

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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