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Predicting neurodegeneration in living patients by IR imaging of skin fibroblasts

Award Number: R21AG077458
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Predicting neurodegeneration in living patients by IR imaging of skin fibroblasts - ABSTRACT Although neurodegenerative diseases most often can be identified by late onset behavioral characteristics or by post-mortem pathology, we often lack reliable methods to predict disease status early in life. It remains extraordinarily difficult in many cases to make clear distinctions among neurodegenerative disease subtypes before the onset of symptoms, or to determine when disease onset will occur. New biomarkers are needed. We have developed a Fourier transform infrared (FTIR) spectromicroscopy approach to predict disease status from cell images based on chemical endpoints. Cells are exposed to IR light and spectral phenotyping ofthe cell images produces an absorbance signature as a rapid physiological indicator of disease state. We will test whether the method can accurately classify disease status in the absence of behavioral or tissue abnormalities and benchmark the predictions in mice with known disease features. In human cells, we will test whether the FTIR biomarker can accurately predict neurodegenerative disease class using human patient fibroblasts and lymphoblasts as surrogate cells. The FTIR spectrum will be tested to distinguish among neurodegenerative subtypes that are often confused with each other, e.g., Alzheimer’s disease (AD) and non-AD dementias. These proof of principle experiments are designed to establish whether the FTIR method can generate a reliable early disease biomarker and whether the signature has the power to discriminate among distinct disease subtypes. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$251 )
2026	2022	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Aging Research	000	1	1/8/2026	NEW	-$251
														Subtotal = -$251

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Aging Research	000	1	5/2/2024	NEW	$0
2024	2022	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Aging Research	001	1	9/19/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $541,295 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Aging Research	001	1	8/8/2022	NEW	$0
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Aging Research	000	1	7/21/2022	NEW	$541,295
														Subtotal = $541,295

Grand Total All Awards = $541,044

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Predicting neurodegeneration in living patients by IR imaging of skin fibroblasts

Award Number: R21AG077458

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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