Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

Award Number: R21AG075379
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2025

Group Awards By:

View Award Description

Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes - Abstract Exercise training produces substantial health benefits, summarized in the Physical Activity Guidelines Advisory Committee Report and incorporated into the 2008 and 2018 Physical Activity Guidelines for Americans. Despite the well-known benefits, too few individuals adopt exercise as a health maintenance strategy. Thus, determining whether a relatively modest duration of exercise training in middle age can lead to sustained health benefits as individuals progress into older age groups (legacy effects) is of public health and clinical importance. In previously sedentary, overweight middle-aged adults with dyslipidemia, our STRRIDE I Reunion study revealed legacy effects for fitness and cardiometabolic risk factors 10 years following exercise intervention; some of these effects were specific to the amount and intensity of exercise performed. In light of the legacy benefits observed in STRRIDE I, the proposed STRRIDE-PD Reunion study seeks to determine the extent to which changes in fitness and cardiometabolic risk factors acquired in individuals aged 45-75 are maintained over a 10-year period in participants from the STRRIDE-Prediabetes (STRRIDE-PD) randomized trial. Importantly, the STRRIDE-PD Reunion will allow us to verify the observed legacy effects of aerobic exercise training in participants at greater risk for cardiometabolic disease. The STRRIDE-PD trial included a group similar to the lifestyle arm of the Diabetes Prevention Program, designed to achieve weight loss through diet and exercise. This unique design element will allow us to compare the ability of different aerobic exercise interventions – with and without weight loss – to elicit sustained cardiometabolic health benefits in adults with prediabetes. Combined with the previous STRRIDE studies, the STRRIDE-PD Reunion will solidify the scientific knowledge exploring the underlying molecular mechanisms by which exercise – differing in amount, intensity, and mode – produces sustained health benefits across the lifespan from age 45 to 85. Overall, findings from this research will demonstrate the power and value of exercise training programs of even modest duration to elicit long-term cardiometabolic health benefits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$1,522 )
2026	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	000	2	12/1/2025	NON-COMPETING CONTINUATION	-$1,522
														Subtotal = -$1,522

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	000	2	12/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $241,500 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	000	2	1/5/2023	NON-COMPETING CONTINUATION	$241,500
														Subtotal = $241,500

Issue Date FY: 2022 ( Subtotal = $361,503 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Aging Research	000	1	2/1/2022	NEW	$201,250
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Aging Research	001	1	9/2/2022	SUPPLEMENT FOR EXPANSION	$160,253
														Subtotal = $361,503

Grand Total All Awards = $601,481

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

Award Number: R21AG075379

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer