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Elucidating the Therapeutic Potential of Cannabidiol (CBD) in Alcohol Dependence: Targeting Neuroadaptations in the Basolateral Amygdala

Award Number: R21AA032100
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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Elucidating the Therapeutic Potential of Cannabidiol (CBD) in Alcohol Dependence: Targeting Neuroadaptations in the Basolateral Amygdala - Project Summary/Abstract Alcohol dependence and withdrawal are associated with significant neuroadaptations in the brain, particularly within the basolateral amygdala (BLA). Cannabidiol (CBD) has shown promise in modulating these neuroadaptations, potentially providing therapeutic benefits for alcohol use disorders. This proposal outlines a comprehensive investigation into the cellular and molecular mechanisms underlying the effects of CBD on alcohol-induced neuroadaptations in the BLA during acute withdrawal and protracted abstinence from alcohol. Specific Aim 1 will determine the impact of chronic CBD treatment on GABAergic and glutamatergic transmission in BLA neurons of naive animals and those during acute withdrawal from alcohol. Additionally, we will examine the effects of CBD on withdrawal-induced Fos activation and cannabinoid receptor levels. Specific Aim 2 will build upon these findings, investigating the long-term effects of CBD on the BLA during protracted abstinence from alcohol. We will explore the impact of CBD on alcohol-induced neuroadaptation in the BLA of animals with a history of alcohol dependence, now in a prolonged abstinence period. The proposed experiments utilize a combination of electrophysiological recordings, RNA scope, and immunohistochemistry techniques to provide a comprehensive understanding of the effects of CBD on alcohol- induced neuroadaptations in the BLA. By elucidating the cellular and molecular mechanisms underlying CBD's influence on alcohol-related neuroadaptations, this research will contribute to the development of novel therapeutic strategies for alcohol use disorders and promote a better understanding of the potential benefits of CBD in the treatment of addiction.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $190,000 )
2026	2026	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	1	9/2/2026	NEW	$190,000
														Subtotal = $190,000

Grand Total All Awards = $190,000

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Elucidating the Therapeutic Potential of Cannabidiol (CBD) in Alcohol Dependence: Targeting Neuroadaptations in the Basolateral Amygdala

Award Number: R21AA032100

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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