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Human Laboratory Screening of Semaglutide for Alcohol Use Disorder

Award Number: R21AA026931
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/10/2019
PERIOD OF PERFORMANCE END DATE: 03/31/2024

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Human Laboratory Screening of Semaglutide for Alcohol Use Disorder - PROJECT SUMMARY Pharmacotherapy development remains a critical objective for reducing health and societal burdens associated with alcohol use disorder (AUD). Developing targeted treatments for specific AUD subgroups is a key aim under the NIAAA medication development strategy. Among those with AUD, cigarette smokers comprise a sizable and critical subgroup with disproportionally high long-term health risks, making it a key priority to advance therapies for concurrent AUD and cigarette smoking. Recent preclinical evidence indicates that glucagon-type peptide-1, an incretin hormone, impacts alcohol motivation and intake. So far, no studies have reported on the effects of GLP-1 receptor medications on aspects of alcohol motivation and reward in human participants. Human laboratory medication trials offer a time- and cost-effective option for validating preclinical findings prior to carrying out larger randomized controlled trials. This project will utilize human laboratory screening procedures to evaluate a GLP-1 receptor agonist as a novel candidate therapy for smokers with AUD. Participants who meet criteria for AUD and report regular light-to-moderate smoking will complete alcohol administration procedures in a within-subjects, counter-balanced design. This study will provide initial human data on the effects of a GLP-1 receptor agonist in relation to alcohol-related outcomes, including both alcohol and nicotine motivation, in participants with AUD. Validation of a candidate monotherapy for joint alcohol and nicotine reduction could have substantial public health impact.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$6,364 )
2024	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	2	7/26/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$6,364
														Subtotal = -$6,364

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	2	12/9/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$12,871
2023	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	002	2	5/10/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2023	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	1	12/9/2022	NEW	-$12,871
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	2	3/8/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$88,329
2022	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	1	3/8/2022	NEW	-$88,329
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $225,436 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	2	9/21/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$225,436
2021	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	1	9/21/2021	NEW	$0
														Subtotal = $225,436

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	1	3/13/2020	NEW	$0
2020	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	001	1	7/28/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $214,657 )
2019	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	000	1	4/10/2019	NEW	$212,258
2019	2019	MIND RESEARCH NETWORK, THE	1101 YALE BLVD NE	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Alcohol Research Programs	001	1	4/23/2019	NEW	$2,399
														Subtotal = $214,657

Grand Total All Awards = $433,729

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Human Laboratory Screening of Semaglutide for Alcohol Use Disorder

Award Number: R21AA026931

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/10/2019

PERIOD OF PERFORMANCE END DATE: 03/31/2024

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