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Novel and improved exposure assessment in childhood cancer (NICE)

Award Number: R16GM165989
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2030

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Novel and improved exposure assessment in childhood cancer (NICE) - PROJECT SUMMARY Cancer is the second leading cause of death in children. Traffic-related exposures are ubiquitous and diesel is an established carcinogen in humans and animals, while green space around the residence may mitigate these health impacts as well increase physical activity. Valid exposure assessment methods in population- based epidemiologic studies are a key factor for identifying and acting on risks that are preventable. Here, this project will assess the roles of traffic-related and other air exposures and green space on childhood cancer risk in a large population-based study. The study team has over a decade of experience building exposure models for air exposures in California and studying fetal development and childhood cancer. The study team has built and validated statewide land use regression models in California for nitrogen dioxide (NO2) and particulate matter <2.5 micrometers in diameter (PM2.5), both with a 30 m x 30 m resolution, a land use regression model of ultrafine PM for the South Coast Air Basin (which encompasses Los Angeles County and parts of Orange and Riverside Counties), and a model of oil and gas development in California. The project will leverage these resources and apply models to an existing study of childhood cancers in California, for which there is already extensive characterization of other environmental exposures (pesticides, ambient industrial agents), and in addition there has been well-described confounding information including perinatal and gestational risk factors. This project will characterize risk in both more common and rarer, understudied cancers. Graduate and undergraduate student research assistants will be involved on all parts of this project including but not limited to using ArcGIS, data cleaning and management, statistical programming, presentation of findings, manuscript preparation, human subjects protection, data security, and project management. Results will provide necessary evidence for larger scale studies of exposure biomarkers, encourage policies to protect pregnant women and children, and provide opportunities for population-based prevention of pediatric cancers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $149,460 )
2026	2026	UNIVERSITY OF NORTH TEXAS	1112 DALLAS DR STE 4000	DENTON	TX	76205	DENTON	USA	Biomedical Research and Research Training	000	1	7/24/2026	NEW	$149,460
														Subtotal = $149,460

Grand Total All Awards = $149,460

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Novel and improved exposure assessment in childhood cancer (NICE)

Award Number: R16GM165989

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2030

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