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Cooperative Catalysis Using Earth Abundant Metals

Award Number: R16GM160795
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/04/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Cooperative Catalysis Using Earth Abundant Metals - Project Summary Homogeneous transition metal catalysis is one of the most significant tools in drug discovery and biomedical research. The development of practical, environmentally friendly catalysts remains an important goal in medicinal and process chemistry, as the sustainable development of new medicines is dependent on the availability of a diverse set of synthetic methods. However, the pharmaceutical and chemical industry is over-reliant on precious metal elements which are scarce, toxic and, expensive. This proposal describes research into novel metal complexes based upon abundant 1st-row metalate species for application in catalytic transformations of biologically relevant small molecules. In Aim 1 of the proposal, we will develop and investigate the structural and electronic features of a new class of metal complexes in unusually low oxidation states and supported by N- heterocyclic phosphenium ions (NHPs). This knowledge will then be used to facilitate the development of functional catalysts. In Aim 2, the development of metalate-catalyzed transformations will be investigated. A major focus will be on the development of small molecule functionalization using careful mechanistic analysis of the novel pathways likely to emerge from the use of unprecedented metalate catalysts. The new catalysts and transformations developed in this proposal will allow medicinal and process chemists the ability to conserve valuable and non-sustainable resources (precious metals) which represent a key technology in drug development. These approaches will in turn be useful in the preparation of new materials and medicines to further biomedical research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $147,025 )
2025	2025	UNIVERSITY OF CALIFORNIA, MERCED	5200 N LAKE RD	MERCED	CA	95343	MERCED	USA	Biomedical Research and Research Training	000	1	8/4/2025	NEW	$147,025
														Subtotal = $147,025

Grand Total All Awards = $147,025

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Cooperative Catalysis Using Earth Abundant Metals

Award Number: R16GM160795

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/04/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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