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Developing Digital Speech Biomarkers of Bulbar Disease Decline in Spanish-Speaking persons with Amyotrophic Lateral Sclerosis

Award Number: R16GM159802
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/13/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2029

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Developing Digital Speech Biomarkers of Bulbar Disease Decline in Spanish-Speaking persons with Amyotrophic Lateral Sclerosis - . ALS is a rapidly progressive neurodegenerative disease in which 90% of patients will experience loss of speech and swallowing, significantly impacting quality of life and survival. Although the loss of speech and swallowing functions have been cited as the worst aspects of the disease, little is known about the trajectory of bulbar disease decline and thus interventions are primarily reactive in nature. Recent advances in remote data collection have enabled the assessment of bulbar decline through speech recordings; however, these tools have been validated exclusively in English, limiting their applicability to Spanish-language speakers. The primary aim of this project is to develop and validate digital biomarkers of bulbar decline in Spanish-speaking persons with ALS (pALS). Speech and respiratory parameters will be collected using a smartphone application in Spanish and compared to equivalent measures from Spanish-speaking caregivers, clinical outcomes (Spanish ALS Functional Rating Scale), and across ALS phenotypes (Aim 1). Additionally, we will assess the sensitivity of maximum phonation time in detecting changes in respiratory function (Aim 2). The project leverages innovative technology to improve disease management for pALS, enabling earlier detection of bulbar disease decline and earlier intervention to extend functional independence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $149,695 )
2025	2025	NOVA SOUTHEASTERN UNIVERSITY, INC	3300 S UNIVERSITY DR	FT LAUDERDALE	FL	33328	BROWARD	USA	Biomedical Research and Research Training	000	1	8/13/2025	NEW	$149,695
														Subtotal = $149,695

Grand Total All Awards = $149,695

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Developing Digital Speech Biomarkers of Bulbar Disease Decline in Spanish-Speaking persons with Amyotrophic Lateral Sclerosis

Award Number: R16GM159802

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/13/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2029

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