Wednesday, September 17, 2025 9/17/2025

Bioluminescent FAK Sensor and Genome-Wide CRISPR Knockout Screen to Identify Regulators of Cellular Adhesion

Award Number: R16GM158720
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2029

Group Awards By:

View Award Description

Bioluminescent FAK Sensor and Genome-Wide CRISPR Knockout Screen to Identify Regulators of Cellular Adhesion - This project leverages a combination of bioluminescence-controlled transcription and robust genome-wide CRISPR screening, the research will map the regulation of Focal Adhesion Kinase (FAK) activity and help elucidate the complex genetic networks that govern cellular adhesion and locomotion, advancing the field of cellular biology. The project is structured to make a significant impact in several ways. Firstly, by developing a bioluminescent kinase sensor, BlinKS, for FAK, the project aims to provide real-time insights into kinase activity within living cells, a breakthrough in observing dynamic cellular processes. The integration of this sensor with genome-wide CRISPR knockout screens will enable the identification of novel genes that regulate FAK signaling pathways. This could potentially lead to the discovery of new molecular targets for therapies in diseases where FAK plays a crucial role, such cancer metastasis and wound healing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $144,961 )
2025	2025	CENTRAL MICHIGAN UNIVERSITY	119 BOVEE UNIVERSITY CTR	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Biomedical Research and Research Training	000	1	7/30/2025	NEW	$144,961
														Subtotal = $144,961

Grand Total All Awards = $144,961

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Bioluminescent FAK Sensor and Genome-Wide CRISPR Knockout Screen to Identify Regulators of Cellular Adhesion

Award Number: R16GM158720

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer