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Mathematical Models for Obesity-Induced Type 2 Diabetes Mellitus and Chronic Wound Healing

Award Number: R16GM154782
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/03/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Mathematical Models for Obesity-Induced Type 2 Diabetes Mellitus and Chronic Wound Healing - Project Summary Aim: To develop a predictive mathematical model of obesity-induced diabetes and chronic wound that includes a realistic representation of the main physiological factors that are correlated with high prevalence of type 1/type 2 diabetes, and that also take into account a more detailed process of glucose/glycogen exchange in the liver. The Need: Obesity is a risk factor for several diseases, two of which are diabetes and chronic wounds: 85% of adult Americans with type 2 diabetes mellitus (T2DM) are overweight or obese, and 30% of obese adults have the disease. Studies have identiﬁed causes, mechanisms and obesity-related glucose/glycogen exchange factors which impair healing of dermal wounds; these factors have been represented by constant parameter so far. The overall premises of this proposal is to focus on better understanding the role of these factor and model them by variable functions. The Opportunity: Recent work have identiﬁed four main factors that are correlated with the high prevalence of type 1/type 2 diabetes, and which impair healing of dermal wounds in diabetes patients: D1 = excessive production of glucagon, D2 = excessive production of leukotrient, D3 = decreased production of stromal cell- derived factor-1, and D4 = insulin resistance. However, these work main deﬁciencies were to take the Di's as constant parameters. To make this model predictive, one must derive the Di's based on the dynamics of glucose associated with obesity. But since this dynamics is also associated with obesity-induced diabetes, there is need to develop this aspect as well. Some initial work already begun in our lab in this regard, where developed a mathematical model that includes the mechanisms of glucose transport from the blood to the liver,and from the liver to the blood, and explains how obesity is likely to lead to lead to T2DM, and used the model to evaluate the efﬁcacy of an anti-T2DM drug that also reduces weight. However, here again there are some parameters that were taken as constants, and again, to be a predictive model, these parameters will need to be dynamics. The Impact: Success in this work will open up entirely new ways to design and analyze within-host mathe- matical models in general, and those of glucose-insulin dynamical systems in health and in the case of obesity- induced diabetic chronic wounds in particular. We anticipate direct practical applicability as our modeling techniques could be replicated and our conclusions used as hypotheses for clinical trials. Hence, this project offers a potential to reinvent the modeling of glucose-insulin dynamical system in obese-induced diabetic chronic wounds by enhancing the quality of virtual patients development, necessary for assessing new experimental or approved drugs. Moreover, the same concepts readily translate to a wide range of important chronic infections/diseases such as cancers, hepatitis B virus, and osteoporosis among others.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $176,840 )
2025	2025	ROCHESTER INSTITUTE OF TECHNOLOGY	1 LOMB MEMORIAL DR	ROCHESTER	NY	14623	MONROE	USA	Biomedical Research and Research Training	000	2	7/18/2025	NON-COMPETING CONTINUATION	$176,840
														Subtotal = $176,840

Issue Date FY: 2024 ( Subtotal = $176,840 )
2024	2024	ROCHESTER INSTITUTE OF TECHNOLOGY	1 LOMB MEMORIAL DR	ROCHESTER	NY	14623	MONROE	USA	Biomedical Research and Research Training	000	1	9/3/2024	NEW	$176,840
														Subtotal = $176,840

Grand Total All Awards = $353,680

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Mathematical Models for Obesity-Induced Type 2 Diabetes Mellitus and Chronic Wound Healing

Award Number: R16GM154782

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/03/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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