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Assessing if tumor induced muscle cachexia is initiated by defects in Myosin Heavy Chain production and localization in a Drosophila tumor model

Award Number: R16GM150753
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Assessing if tumor induced muscle cachexia is initiated by defects in Myosin Heavy Chain production and localization in a Drosophila tumor model - Cachexia is a devastating cancer associated disease which affects millions each year and yet is untreatable. Currently cachexia is defined in patients by rapid loss of >5% of body weight with muscle weakness and an underlying chronic condition. Cachexia is considered a late-stage consequence of cancer. Here, we present preliminary data acquired by undergraduate students using a Drosophila model of cancer cachexia. Excitingly, we have identified stereotyped changes which occur in vivo early in tumor development. In this study, we will distinguish the origins of these phenotypes, assess their contribution to cachexia progression, and investigate if the Hippo signaling pathway is regulating early or late events in cachexia. We will leverage our expertise in staining and imaging as well as new community tools which allow tissue specific genetic manipulation to achieve our goals. These studies will be conducted primarily by undergraduate trainees and will shed light on the unknown etiology of cancer-induced cachexia. Results of these, and future translational works, are the foundation to developing earlier diagnostics permitting interventions to prevent cachexic progression in patients. Through the course of this support the PI will establish an independent research program which will illuminate the earliest steps of cachexic changes in muscles and provide critical training and support to outstanding and meritorious undergraduate and master’s degree seeking trainees to support the future development of our critical health and scientific workforce.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $171,250 )
2026	2026	SAM HOUSTON STATE UNIVERSITY	1806 AVE J	HUNTSVILLE	TX	77341	WALKER	USA	Biomedical Research and Research Training	000	4	7/17/2026	NON-COMPETING CONTINUATION	$171,250
														Subtotal = $171,250

Issue Date FY: 2025 ( Subtotal = $171,250 )
2025	2025	SAM HOUSTON STATE UNIVERSITY	1806 AVE J	HUNTSVILLE	TX	77341	WALKER	USA	Biomedical Research and Research Training	000	3	7/24/2025	NON-COMPETING CONTINUATION	$171,250
														Subtotal = $171,250

Issue Date FY: 2024 ( Subtotal = $171,250 )
2024	2024	SAM HOUSTON STATE UNIVERSITY	1806 AVE J	HUNTSVILLE	TX	77341	WALKER	USA	Biomedical Research and Research Training	000	2	7/9/2024	NON-COMPETING CONTINUATION	$171,250
														Subtotal = $171,250

Issue Date FY: 2023 ( Subtotal = $169,880 )
2023	2023	SAM HOUSTON STATE UNIVERSITY	1806 AVE J	HUNTSVILLE	TX	77341	WALKER	USA	Biomedical Research and Research Training	000	1	9/12/2023	NEW	$169,880
														Subtotal = $169,880

Grand Total All Awards = $683,630

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Assessing if tumor induced muscle cachexia is initiated by defects in Myosin Heavy Chain production and localization in a Drosophila tumor model

Award Number: R16GM150753

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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