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Analysis of Divergent Transcripts in Estrogen-Dependent Signaling

Award Number: R16GM149497
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Analysis of Divergent Transcripts in Estrogen-Dependent Signaling - Project Summary The endocrine hormone estrogen (E2) actions by binding to its estrogen-receptor alpha (ERα), stimulates a robust mitogenic response in ER+ cells. In this regard, signal-regulated divergent transcription and its products have emerged as an important class of molecules that regulate various endocrine pathways such as estrogen and androgen signaling. Recent studies suggest that divergent transcripts are cell- and tissue-specifically expressed, and the E2-regulated divergent transcription is critical to eliciting full E2-driven gene expression. E2 signaling triggers a highly coordinated transcriptional program, leading to a robust mitogenic response that drives different cellular activities. Understanding the molecular mechanisms through which divergent transcription or transcripts regulate E2-responsive, ERα-dependent transcription will increase our understanding of the diseases caused by aberrant E2-signaling. Deciphering the molecular mechanisms of action of divergent transcripts in ER+ cells will be very important. In the preliminary study involving cellular and genomic approaches, E2- regulated divergent RNAs were identified and annotated. In addition, the initial characterization of a novel E2- regulated divergent transcript suggests that it controls E2-driven cellular processes and gene expression. In the current proposal, the molecular mechanisms by which divergent transcripts regulate E2-dependent signaling will be determined. The overarching hypothesis is that specific biochemical and structural properties of divergent transcripts underlie their ability to control critical E2-dependent pathways. A complementary set of biochemical, molecular, cell-based, proteomic, and genomic assays will be used to study the molecular mechanisms by which divergent transcript regulates E2-dependent transcription and growth of ER+ cells: specifically (1) Aim 1 will determine the molecular mechanisms of action of E2-regulated divergent transcript, in E2-dependent signaling, and (2) Aim 2 will identify the mechanism by which divergent transcripts control the assembly of E2-dependent gene regulatory complex. Successful completion of these aims will yield a new understanding of how divergent transcripts control key E2-dependent cellular pathways.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$10,000 )
2026	2025	TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO	130 RICK FRANCIS ST	EL PASO	TX	79905	EL PASO	USA	Biomedical Research and Research Training	000	3	2/23/2026	NON-COMPETING CONTINUATION	-$159,999
2026	2025	THE UNIVERSITY OF TEXAS RIO GRANDE VALLEY	1201 W UNIVERSITY DR	EDINBURG	TX	78539	HIDALGO	USA	Biomedical Research and Research Training	001	4	2/25/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$149,999
														Subtotal = -$10,000

Issue Date FY: 2025 ( Subtotal = $160,000 )
2025	2025	TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO	130 RICK FRANCIS ST	EL PASO	TX	79905	EL PASO	USA	Biomedical Research and Research Training	000	3	9/10/2025	NON-COMPETING CONTINUATION	$160,000
														Subtotal = $160,000

Issue Date FY: 2024 ( Subtotal = $160,000 )
2024	2024	TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO	130 RICK FRANCIS ST	EL PASO	TX	79905	EL PASO	USA	Biomedical Research and Research Training	000	2	7/29/2024	NON-COMPETING CONTINUATION	$160,000
														Subtotal = $160,000

Issue Date FY: 2023 ( Subtotal = $160,000 )
2023	2023	TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO	5001 EL PASO DR	EL PASO	TX	79905	EL PASO	USA	Biomedical Research and Research Training	000	1	9/7/2023	NEW	$160,000
														Subtotal = $160,000

Grand Total All Awards = $470,000

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Analysis of Divergent Transcripts in Estrogen-Dependent Signaling

Award Number: R16GM149497

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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