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Adolescent alcohol exposure: impact on neuronal activation, steroids, and metabolomic profiles

Award Number: R16GM149485
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Adolescent alcohol exposure: impact on neuronal activation, steroids, and metabolomic profiles - Scientific Abstract Alcohol use disorders are a major public health concern afflicting approximately 17 million Americans, often beginning with binge drinking during adolescence. In recent years drinking in adolescent females has surpassed that of adolescent males. However, the sex-specific neurobiological mechanisms underlying the impact of adolescent binge drinking are not well understood. We have previously shown sex-specific changes in behavioral and brain protein changes following adolescent intermittent ethanol (AIE) exposure. In the proposed work, we focus on sex steroid regulation of neuronal activation with a particular emphasis on the medial prefrontal cortex. Sex steroids are critically important for pubertal hormonal function and is altered by early alcohol exposure. Specifically, we examine the long-lasting sex-specific changes induced by AIE exposure with withdrawal in male and female mice. If binge alcohol exposure changes normal adolescent brain development, alterations in neuronal activation in sex steroid containing neurons likely plays an important role in the lasting effects of adolescent binge alcohol exposure and increased susceptibility to development of an alcohol use disorder. Aim 1 will determine (1) sex-specific and time-dependent changes in neuronal activation and steroid receptors in mesocorticolimbic brain structures after withdrawal from AIE and ethanol re-exposure. Aim 2 will determine sex- specific and time-dependent changes in metabolomic and sex steroid profiles after withdrawal from AIE and ethanol re-exposure. Aim 3 will determine if activation/inhibition of medial prefrontal cortex (mPFC) after AIE exposure impacts subsequent ethanol drinking. Completion of this work will elucidate short- and long-term impacts of adolescent ethanol exposure on neuronal activity in steroid receptor containing neurons in mesocorticolimbic regions, metabolic and sex steroid profiles, and prefrontal regulation of subsequent ethanol drinking behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $141,912 )
2024	2024	NORTH CAROLINA AGRICULTURAL AND TECHNICAL STATE UNIVERSITY	1601 E MARKET ST	GREENSBORO	NC	27411	GUILFORD	USA	Biomedical Research and Research Training	000	2	8/27/2024	NON-COMPETING CONTINUATION	$141,912
														Subtotal = $141,912

Issue Date FY: 2023 ( Subtotal = $141,912 )
2023	2023	NORTH CAROLINA AGRICULTURAL AND TECHNICAL STATE UNIVERSITY	1601 E MARKET ST	GREENSBORO	NC	27411	GUILFORD	USA	Biomedical Research and Research Training	000	1	8/31/2023	NEW	$141,912
														Subtotal = $141,912

Grand Total All Awards = $283,824

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Adolescent alcohol exposure: impact on neuronal activation, steroids, and metabolomic profiles

Award Number: R16GM149485

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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