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Development of a photothermal stimulator array for controlled neuron stimulation

Award Number: R16GM145601
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/05/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Development of a photothermal stimulator array for controlled neuron stimulation - Project Summary/Abstract Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), affect more than 10 million Americans. Unfortunately, many patients eventually suffer vision loss due to no available therapeutic cure for these diseases. Retinal prosthesis is the only available option to make artificial interfaces to restore a damaged neural path. Electrical stimulation-based retinal prostheses have been most widely used due to their conceptual simplicity. However, it faces many hurdles due to complex signal interfaces, especially for high spatial resolution. A novel approach based on the principle of stimulating neuronal cells with a direct optical-induced thermal signal is introduced to potentially offer more advantages over the electrical stimulation approach. However, the concept is relatively new, and necessary engineered means should be developed to translate this approach to retinal prostheses. The goal of the proposed research is to create a two-dimensional array of photothermal pixels, of which the thermal stimulation is directly controlled by incoming light images. Based on the optical stimulation approach, this will address many challenges that the current electrical stimulation face, especially for large area stimulation. Successful completion of the proposed research will represent a revolutionary advance on the photothermal-based stimulation method and open a new opportunity of using photothermal stimulation in retinal prostheses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $157,455 )
2025	2025	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	160 CONVENT AVE	NEW YORK	NY	10031	NEW YORK	USA	Biomedical Research and Research Training	000	4	8/15/2025	NON-COMPETING CONTINUATION	$157,455
														Subtotal = $157,455

Issue Date FY: 2024 ( Subtotal = $157,452 )
2024	2024	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	160 CONVENT AVE	NEW YORK	NY	10031	NEW YORK	USA	Biomedical Research and Research Training	000	3	8/14/2024	NON-COMPETING CONTINUATION	$157,452
														Subtotal = $157,452

Issue Date FY: 2023 ( Subtotal = $226,860 )
2023	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	160 CONVENT AVE	NEW YORK	NY	10031	NEW YORK	USA	Biomedical Research and Research Training	000	2	8/2/2023	NON-COMPETING CONTINUATION	$139,900
2023	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	160 CONVENT AVE	NEW YORK	NY	10031	NEW YORK	USA	Biomedical Research and Research Training	001	2	8/31/2023	SUPPLEMENT FOR EXPANSION	$86,960
														Subtotal = $226,860

Issue Date FY: 2022 ( Subtotal = $134,200 )
2022	2022	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	160 CONVENT AVE	NEW YORK	NY	10031	NEW YORK	USA	Biomedical Research and Research Training	000	1	9/2/2022	NEW	$134,200
														Subtotal = $134,200

Grand Total All Awards = $675,967

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Development of a photothermal stimulator array for controlled neuron stimulation

Award Number: R16GM145601

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/05/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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