Thursday, November 21, 2024
11/21/2024
PROJECT SUMMARY / ABSTRACT This is an application for an administrative supplement to the original R15 application "Arousal and Timekeeping in a Mouse Mode of Parkinsonism" to extend our studies to mouse models of Alzheimer's Disease. Neurodegenerative disorders like Parkinson’s Disease (PD), Huntington’s Disease, and Alzheimer's Disease (AD) are characterized by drastic impairments in planning, as well as cognitive deficits, some of which stem from deficits in estimating durations. Estimation and reproduction of durations in the seconds-to-minutes range are critical for fundamental processes such as associative learning, planned motor responses and decision-making. We propose to extend the original project to evaluate timed motor response deficits in a mouse model of AD. We will investigate the role of arousal in alterations of timed response selection using a newly developed model of timed response selection deficits. We will also evaluate pharmacological approaches to rescue motor timing deficits. The project will enhance our understanding of neuronal processes involved in cognitive and motor control deficits in neurodegenerative disorders, and will help develop new treatment strategies in animal models, with possible subsequent impact on clinical treatments.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).
