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PROVIDE NEW INSIGHTS IN ALPHA-SYNUCLEIN INDUCED CELL MEMBRANE DISRUPTION USING SCANNING ION CONDUCTANCE MICROSCOPY AND SURFACE PLASMON RESONANCE MICROSCOPY

Award Number: R15NS120157
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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PROVIDE NEW INSIGHTS IN ALPHA-SYNUCLEIN INDUCED CELL MEMBRANE DISRUPTION USING SCANNING ION CONDUCTANCE MICROSCOPY AND SURFACE PLASMON RESONANCE MICROSCOPY - Abstract: Parkinson’s disease (PD) is a leading neurodegenerative disorder attributed to the abnormal folding and aggregation of alpha-synuclein (α-syn) in dopaminergic neurons. The exact causative mechanism, however, remains unclear. Leveraging advanced techniques like scanning ion conductance microscopy (SICM) and surface plasmon resonance microscopy (SPRM), our previous work elucidated how α-synuclein oligomers might compromise neuronal membranes, while pre-formed fibrils (PFFs) primarily influence membrane roughness without inducing significant cytotoxicity. This new phase aims to deepen our understanding by exploring the role of phosphorylated α-syn (P-syn), a pathological variant of α-syn. The objectives include synthesizing and characterizing P-syn, assessing its impact on neuronal membranes, and evaluating its influence on iron-driven dopamine oxidation. Furthermore, we will investigate the role of environmental toxins, specifically nanoplastics, in α-syn aggregation and its subsequent interactions with membranes. The outcomes from this research are anticipated to shed light on the molecular intricacies of PD and potentially pave the way for targeted therapeutic strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	CAL STATE LA UNIVERSITY AUXILIARY SERVICES INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	3/19/2025	COMPETING CONTINUATION	$27
2025	2020	CAL STATE LA UNIVERSITY AUXILIARY SERVICES INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/19/2025	NEW	-$27
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $438,000 )
2024	2024	CAL STATE LA UNIVERSITY AUXILIARY SERVICES INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	8/1/2024	COMPETING CONTINUATION	$438,000
2024	2020	CAL STATE LA UNIVERSITY AUXILIARY SERVICES INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/24/2024	NEW	$0
														Subtotal = $438,000

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	CAL STATE LA UNIVERSITY AUXILIARY SERVICES INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/7/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $409,344 )
2020	2020	CAL STATE L.A. UNIVERSITY AUXILIARY SERVICES, INC.	5151 STATE UNIVERSITY DR GE 314	LOS ANGELES	CA	90032	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/18/2020	NEW	$409,344
														Subtotal = $409,344

Grand Total All Awards = $847,344

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PROVIDE NEW INSIGHTS IN ALPHA-SYNUCLEIN INDUCED CELL MEMBRANE DISRUPTION USING SCANNING ION CONDUCTANCE MICROSCOPY AND SURFACE PLASMON RESONANCE MICROSCOPY

Award Number: R15NS120157

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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