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The neuropathology of cerebellum in spinal muscular atrophy

Award Number: R15NS120154
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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The neuropathology of cerebellum in spinal muscular atrophy - This is a resubmission (A1) of application 1R15 NS120154-01, “The neuropathology of cerebellum in spinal muscular atrophy”, which was reviewed in June 2020 at the ZRG1 MDCN-R (86) section. Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality. It arises from the mutation of the survival motor neuron one (SMN1) gene. Despite decades of research, its mechanisms of neuropathology are far from clear. The recent US FDA approved SMN restoration therapies (Nusinersen, Zolgensma, and Risdiplam) are effective in rescuing the motor dysfunction but not cure for SMA. It is not clear how long the effect will last, nor whether patients will suffer problems due to dysfunction of SMN deficient neurons in other parts of the nervous system. Accumulating evidence suggests that low levels of SMN not only alter the function of spinal motor neurons, but also of neurons and neural circuits in other parts of the motor network. However, currently there is little understanding of neuronal pathology in SMA beyond the spinal cord motor neuron (MN) circuit. As new treatments allow patients to live longer, knowledge of the role of central motor network in the neuropathology of SMA will be key for developing long-term prognoses and treatment strategies for patients. The objective of this application is to investigate cerebellar pathology and neural circuit dysfunction in SMA mouse models using magnetic resonance imaging (MRI) and electrophysiological techniques. The rational for this project is based on the important role of cerebellum in motor control, the reports of cerebellar pathology in human SMA patients, as well as our preliminary data showing alterations in the structure and function of cerebellar neural network in mouse models of SMA. Our central hypothesis is that in SMA, alterations in the neurons and neural circuits of the cerebellum decrease cerebellar output and alter descending motor commands from the motor cortex and brainstem to the spinal cord, contributing to neuropathology and motor system dysfunction. This central hypothesis will be tested by three specific aims: 1) Identify changes in the morphology and fiber connections of the cerebellum in SMNΔ7 and MN rescue mice by magnetic resonance imaging techniques; 2) Elucidate the functional alteration of cerebellar neurons and neural circuits related to SMA pathophysiology using electrophysiological techniques; 3) Relate changes in cerebellar structure and neural circuit function to SMA disease progression in MN rescue mouse model. To determine the contribution of structural and functional pathology in the cerebellum to the phenotype of SMA, we will use MRI and electrophysiology to investigate the development of neuropathology in the cerebellum at pre-symptomatic (postnatal day 3–4, P3–P4), early- (P7–P8), and end-symptomatic (P12–P13) stage of SMA. The comparison studies between SMNΔ7 and motor neuron MN mouse models will confirm and elucidate the correlation of cerebellar neuropathology with spinal motor neuron dysfunction in SMA mice. Identifying the start and progression of cerebellar neuropathology will indicate how cerebellar structural or functional pathology or both contribute to the SMA phenotype. The proposed research is innovative because it will be the first thorough study of the dysfunction and its mechanisms of the cerebellar neural network in SMA mice with a unique combination of electrophysiological, MRI and immunohistochemical techniques. This kind of study is required to develop a complete systematic understanding of the pathophysiology of SMA, and almost no studies so far have investigated the critical issue of dysfunction in the brain network and its contribution to motor dysfunction. The proposed research is significant because understanding specific abnormalities cerebellar network can lead to new targets for potential therapeutics aimed at preserving motor function in SMA patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	DELAWARE STATE UNIVERSITY	1200 N DUPONT HWY	DOVER	DE	19901	KENT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/20/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $400,839 )
2022	2022	DELAWARE STATE UNIVERSITY	1200 N DUPONT HWY	DOVER	DE	19901	KENT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/15/2022	NEW	$400,839
														Subtotal = $400,839

Grand Total All Awards = $400,839

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The neuropathology of cerebellum in spinal muscular atrophy

Award Number: R15NS120154

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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