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Brain Macrophages After Brain Injury Leads to Negative Behavioral Outcomes

Award Number: R15NS116601
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Brain Macrophages After Brain Injury Leads to Negative Behavioral Outcomes - Project Summary: TBI is a serious public health concern, and in 2014 alone 2.53 million emergency visits, hospitalizations, and death occurred in USA. In human post-mortem studies, accumulation of microglia/monocyte-derived macrophages (MDM), the key mediators of chronic neuroinflammation were detected, even after several years of TBI. Microglia -the resident immune cells- maintain the delicate neuronal microenvironment under physiological conditions through surveillance and proliferate when needed under injury or pathological conditions. Upon injury to the CNS from TBI, monocytes enter the brain and differentiate into MDM, and become morphologically indistinguishable from the activated microglia. Microglia/MDMs have been reported to contribute significantly to traumatic brain injury (TBI) pathology. However, it remains unclear how monocytes/MDM are functionally distinct from microglia at the subcellular (RNA), cellular, and network levels. Our central hypothesis is that after TBI, microglia and MDM contribute differently to the chronic inflammatory response, neuronal excitability, and behavioral deficits. Hence, the objective of this study is to develop an in-depth understanding of: i) how mRNA changes in MDMs/microglia affect injury progression, ii) how they interact with each other and blood vessels, and iii) how MDMs influence neuronal activity and subsequent behavioral outcomes, compared to resident microglia. This understanding may help the development of effective diagnostics, prognostics and therapeutics. Our proposal to use double transgenic reporter mice, RNA sequencing, chronic-two photon imaging and electrophysiological tools in blast TBI condition is the very first attempt to provide the needed knowledge.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$6 )
2026	2021	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/19/2026	NEW	-$6
														Subtotal = -$6

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/15/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	10/25/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $384,725 )
2021	2021	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/6/2021	NEW	$384,725
														Subtotal = $384,725

Grand Total All Awards = $384,719

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Brain Macrophages After Brain Injury Leads to Negative Behavioral Outcomes

Award Number: R15NS116601

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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