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Multi-limb Control in Parkinson's Disease: Implicit and Explicit Control of Attention

Award Number: R15NS098340
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2017
PERIOD OF PERFORMANCE END DATE: 08/31/2021

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Multi-limb Control in Parkinson's Disease: Implicit and Explicit Control of Attention - ABSTRACT Driving and walking are important aspects of everyday life, yet car crashes and falls pose serious public health concerns. Distraction and multi-tasking while driving or walking often lead to disastrous results, indicating the importance of attention and cognition for safe mobility in the community. Parkinson disease (PD) affects over 1 million Americans at an annual cost of $25 billion, and specifically impacts attention and the ability to dual- task. Drivers with PD are at particular risk for driving cessation or crashes due to progressive difficulties in motor function and cognition that can lead to loss of independence, depression, isolation, and less participation in the community. A characteristic feature of cognitive impairment in PD is difficulty to begin or change self- initiated movement based on implicit cues. People with PD rely more heavily on external cues to overcome their slowed and small movements. For example, stepping to the beat of a metronome or stepping to lines on the floor improves walking. We will test the hypothesis that PD reduces the ability to flexibly allocate attention between arm and foot tasks based on accuracy constraints. Aim 1: Compare the effects of explicit instruction of task prioritization with implicit accuracy demands on shifts in attention during concurrent reaching and foot- pedal tracking tasks in participants with PD and age-matched healthy old adults. Aim 2: Compare the effects of explicit instruction of task prioritization with implicit accuracy demands on shifts in attention during lane-keeping (steering) and car-following (braking/accelerating) behavior during simulated driving performance in drivers with PD and in age-matched healthy old adults. Aim 3: Identify the effect of dopaminergic medication state on attention switching to explicit and implicit cues during driving-like tasks and simulated driving performance behavior in adults with PD. The long-term goal of this research is to characterize impairments in dual task abilities for driving and develop and implement intervention programs to reduce driving difficulties for people with PD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2017	A. T. STILL UNIVERSITY OF HEALTH SCIENCES	800 W JEFFERSON ST	KIRKSVILLE	MO	63501	ADAIR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/14/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	A. T. STILL UNIVERSITY OF HEALTH SCIENCES	800 W JEFFERSON ST	KIRKSVILLE	MO	63501	ADAIR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/30/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	A. T. STILL UNIVERSITY OF HEALTH SCIENCES	800 W JEFFERSON ST	KIRKSVILLE	MO	63501	ADAIR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/14/2018	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $384,317 )
2017	2017	A. T. STILL UNIVERSITY OF HEALTH SCIENCES	800 W JEFFERSON ST	KIRKSVILLE	MO	63501	ADAIR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	9/13/2017	NEW	-$49,258
2017	2017	A. T. STILL UNIVERSITY OF HEALTH SCIENCES	800 W JEFFERSON ST	KIRKSVILLE	MO	63501	ADAIR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	9/5/2017	NEW	$3,075
2017	2017	A. T. STILL UNIVERSITY OF HEALTH SCIENCES	800 W JEFFERSON ST	KIRKSVILLE	MO	63501	ADAIR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/21/2017	NEW	$430,500
														Subtotal = $384,317

Grand Total All Awards = $384,317

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Multi-limb Control in Parkinson's Disease: Implicit and Explicit Control of Attention

Award Number: R15NS098340

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2017

PERIOD OF PERFORMANCE END DATE: 08/31/2021

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