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Synaptic Vesicle Dynamics at Hippocampal Synapses

Award Number: R15NS095318
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Regulated neurotransmitter release is the basis for neuronal communication. Neurotransmitter is stored in synaptic vesicles and released via fusion with the plasma membrane. Consequently, the dynamics that govern synaptic vesicle morphology and function are deterministic for synaptic function. Synaptic vesicle dynamics can be divided into three segments: fusion, retrieval, and restoration. This application proposes to characterize these segments by capturing synaptic vesicles at accurate times after synaptic vesicle fusion and visualizing their dynamic states in the electron microscope. This approach will be complemented with diverse labeling techniques and genetically encoded markers for electron microscopy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$11,608 )
2022	2019	UNIVERSIDAD CENTRAL DEL CARIBE, INC.	100 AVE LAUREL LOMAS VERDES	BAYAMON	PR	00956	BAYAMON	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	001	1	6/29/2022	SUPPLEMENT FOR EXPANSION	-$3,335
2022	2016	UNIVERSIDAD CENTRAL DEL CARIBE, INC.	100 AVE LAUREL LOMAS VERDES	BAYAMON	PR	00956	BAYAMON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	10/1/2021	NEW	-$8,273
														Subtotal = -$11,608

Issue Date FY: 2021 ( Subtotal = -$9,260 )
2021	2019	UNIVERSIDAD CENTRAL DEL CARIBE INC	AVE LAUREL URB SANTA JUANITA	BAYAMON	PR	00956	BAYAMON	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	001	1	11/4/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2019	UNIVERSIDAD CENTRAL DEL CARIBE, INC.	100 AVE LAUREL LOMAS VERDES	BAYAMON	PR	00956	BAYAMON	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	003	1	8/21/2021	SUPPLEMENT FOR EXPANSION	-$1,737
2021	2016	UNIVERSIDAD CENTRAL DEL CARIBE, INC.	100 AVE LAUREL LOMAS VERDES	BAYAMON	PR	00956	BAYAMON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	5/14/2021	NEW	-$7,523
2021	2016	UNIVERSIDAD CENTRAL DEL CARIBE INC	AVE LAUREL URB SANTA JUANITA	BAYAMON	PR	00956	BAYAMON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	10/21/2020	NEW	$0
														Subtotal = -$9,260

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	UNIVERSIDAD CENTRAL DEL CARIBE INC	AVE LAUREL URB SANTA JUANITA	BAYAMON	PR	00956	BAYAMON	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	000	1	4/1/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $154,022 )
2019	2019	UNIVERSIDAD CENTRAL DEL CARIBE INC	AVE LAUREL URB SANTA JUANITA	BAYAMON	PR	00956	BAYAMON	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	001	1	4/16/2019	SUPPLEMENT FOR EXPANSION	$154,022
2019	2016	UNIVERSIDAD CENTRAL DEL CARIBE INC	AVE LAUREL URB SANTA JUANITA	BAYAMON	PR	00956	BAYAMON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/12/2019	NEW	$0
														Subtotal = $154,022

Issue Date FY: 2018 ( Subtotal = $21,837 )
2018	2016	UNIVERSIDAD CENTRAL DEL CARIBE INC	AVE LAUREL URB SANTA JUANITA	BAYAMON	PR	00956	BAYAMON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/11/2018	NEW	$21,837
														Subtotal = $21,837

Issue Date FY: 2016 ( Subtotal = $432,309 )
2016	2016	UNIVERSIDAD CENTRAL DEL CARIBE ESCUELA DE MED DE CAYEY	POST OFFICE BOX 60-327	BAYAMON	PR			USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/14/2016	NEW	$432,309
														Subtotal = $432,309

Grand Total All Awards = $587,300

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Synaptic Vesicle Dynamics at Hippocampal Synapses

Award Number: R15NS095318

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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