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Genetic Analysis of AMPK-alpha in Astrocytes during Normal and Energetic Stress

Award Number: R15NS084329
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/16/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2020

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Genetic Analysis of AMPK-alpha in Astrocytes during Normal and Energetic Stress - Abstract An Academic Research Enhancement Award (AREA) award to promote research at primarily undergraduate institutions (PUIs) –(R15) will greatly impact both my career goals and my undergraduate students and fully meet the intended purpose of this award. Specifically, this award would 1) allow me to pursue my continuing interest in metabolism as it relates to the normal and diseased brain, 2) expose students to relevant research, and 3) support the commitment Trinity University has for scientific research and discovery. During this award period students in my lab will be afforded an exceptional opportunity to obtain training in the field of mouse genetics, cortical development and culturing primary neurons as well as astrocytes, which will enhance their interest in molecular and cellular neuroscience. As a junior faculty member, this award will positively impact the achievement of my long term goals. As a new assistant professor, securing a prestigious award will be pivotal in launching a successful career trajectory as a neurobiology researcher and professor at a PUI. My proposal focuses on AMPK in the nervous system. AMPK is a trimer composed of a catalytic subunit, α, and two regulatory subunits, β and γ. As an energy sensor and regulator of metabolism, AMPK would be expected to play a vital function during neuronal development, maintenance, and survival. However, to date the genetic analysis of AMPKα function in the mammalian nervous system has not been explored. Therefore, this proposal aims to identify molecular mechanisms AMP-activated protein kinase may play in the mammalian nervous system. We will specifically evaluate the in vitro effects of AMPKα1/α2 genetically null astrocytes in autophagy and apoptosis


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2015	WILKES UNIVERSITY	84 W SOUTH ST	WILKES BARRE	PA	18766	LUZERNE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	10/14/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$98,851
2021	2015	WILKES UNIVERSITY	84 W SOUTH ST	WILKES BARRE	PA	18766	LUZERNE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	11/5/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$98,851
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = -$98,851 )
2020	2015	WILKES UNIVERSITY	84 W SOUTH ST	WILKES BARRE	PA	18766	LUZERNE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	9/29/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$98,851
														Subtotal = -$98,851

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2015	WILKES UNIVERSITY	84 W SOUTH ST	WILKES BARRE	PA	18766	LUZERNE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/30/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $349,856 )
2017	2015	WILKES UNIVERSITY	84 W SOUTH ST	WILKES BARRE	PA	18766	LUZERNE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	2	1/24/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$349,856
2017	2015	TRINITY UNIVERSITY	ONE TRINITY PL	SAN ANTONIO	TX	78212	BEXAR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	1/19/2017	NEW	-$349,856
2017	2015	TRINITY UNIVERSITY	ONE TRINITY PL	SAN ANTONIO	TX	78212	BEXAR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	1	1/23/2017	NEW	$0
2017	2015	TRINITY UNIVERSITY	ONE TRINITY PL	SAN ANTONIO	TX	78212	BEXAR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/3/2016	NEW	$0
2017	2015	TRINITY UNIVERSITY	ONE TRINITY PL	SAN ANTONIO	TX	78212	BEXAR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	1/9/2017	NEW	$349,856
														Subtotal = $349,856

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2015	TRINITY UNIVERSITY	715 STADIUM DRIVE	SAN ANTONIO	TX	78284	BEXAR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/13/2016	NEW	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $386,974 )
2015	2015	TRINITY UNIVERSITY	715 STADIUM DRIVE	SAN ANTONIO	TX	78284	BEXAR	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/17/2015	NEW	$386,974
														Subtotal = $386,974

Grand Total All Awards = $637,979

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Genetic Analysis of AMPK-alpha in Astrocytes during Normal and Energetic Stress

Award Number: R15NS084329

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/16/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2020

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