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Trends of disparities in breast cancer progression and health care considering multilevel risk factors

Award Number: R15MD012387
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/07/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Trends of disparities in breast cancer progression and health care considering multilevel risk factors - ABSTRACT Health disparities widely exist in the United States. African Americans and Hispanic populations have higher probabilities of cancer incidence and poor outcomes. There are treatments and policies designed trying to improve health outcomes and reduce disparities. Research methods are needed that help monitor the trend of health disparities, evaluate efficiencies of interventions, identify risk factors that contribute to the start and the change in health disparities, and quantify the effects of identified risk factors. In this study, we propose to develop modern analytical methods that address these requests in research. We propose single- and multi-level moderation analysis methods that adopt recently developed data mining and machine learning techniques in the general mediation analysis. Using these methods, researchers will be able to differentiate and make inferences on effects of risk factors on the observed health disparities from both individual and environmental levels. In addition, we will be able to identify changes of health disparities over time and over employment of new policies. An R package will be developed for the implementation of the proposed novel methods. We will demonstrate the method in 1) identifying the trend of racial disparity in using the Oncotype diagnosis among eligible breast cancer patients, and identifying and making inferences on effects of risk factors that contribute to the change of racial disparity over time; and 2) Investigating the interactive effects of individual factors and social/physical environments on explaining racial disparities in breast cancer outcomes in Louisiana.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = -$12,505 )
2027	2022	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Minority Health and Health Disparities Research	000	2	10/14/2026	COMPETING CONTINUATION	-$12,505
														Subtotal = -$12,505

Issue Date FY: 2025 ( Subtotal = -$1,267 )
2025	2022	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Minority Health and Health Disparities Research	000	2	8/26/2025	COMPETING CONTINUATION	-$1,267
														Subtotal = -$1,267

Issue Date FY: 2023 ( Subtotal = $233,130 )
2023	2023	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Minority Health and Health Disparities Research	000	2	9/18/2023	SUPPLEMENT FOR EXPANSION	$233,130
														Subtotal = $233,130

Issue Date FY: 2022 ( Subtotal = $453,633 )
2022	2022	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Minority Health and Health Disparities Research	001	2	8/7/2022	COMPETING CONTINUATION	$453,673
2022	2017	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Minority Health and Health Disparities Research	000	1	2/15/2022	NEW	-$40
														Subtotal = $453,633

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2017	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Minority Health and Health Disparities Research	000	1	4/8/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Minority Health and Health Disparities Research	000	1	3/18/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $438,000 )
2017	2017	LOUISIANA STATE UNIVERSITY SYSTEM	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Minority Health and Health Disparities Research	000	1	9/24/2017	NEW	$438,000
														Subtotal = $438,000

Grand Total All Awards = $1,110,991

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Trends of disparities in breast cancer progression and health care considering multilevel risk factors

Award Number: R15MD012387

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/07/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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