Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

A Heparin Receptor in Vascular Cells

Award Number: R15HL054269
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/1995
PERIOD OF PERFORMANCE END DATE: 08/31/2025

Group Awards By:

View Award Description

A Heparin Receptor in Vascular Cells - SUMMARY Our identification of TMEM184A as a heparin receptor in vascular cells has led to investigations of how the heparin receptor works in vivo and to further studies of signaling. Saturating the heparin receptor decreases vascular cell proliferation in culture and knocking it down increases endothelial cell proliferation in regenerative angiogenesis. Despite increased cell proliferation, knockdown of the receptor decreases both developmental and regenerative angiogenesis. Our recent studies provide evidence suggesting involvement of the heparin receptor in VEGF signaling as well as in mechano-signaling. Both seem likely to involve direct interactions of the heparin receptor with heparan sulfate proteoglycans. The current proposal is designed to expand our knowledge about the heparin receptor and its function using a combination of cell culture assays, assays of developmental and regenerative angiogenesis in zebrafish, and employing a null mutant for the heparin receptor currently being developed. Specifically, we will test the hypothesis that the heparin receptor interacts with heparan sulfate proteoglycans to modulate signaling. We will also test the hypothesis that mechano-transduction through integrins and VE-Cadherin involves TMEM184A with syndecan 4, and recycling of the components. We will investigate TMEM184A signaling through VEGFR2 where we propose that it modulates the signaling through altering endocytosis pathways leading to altered signaling. Together these studies will provide data to better understand the mechanism(s) by which the heparin receptor is functioning and should yield clues to designing treatments for various vascular diseases that take advance of this heparin receptor modulatory system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2022	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	000	8	3/20/2026	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2018	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	000	7	9/6/2023	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $477,217 )
2022	2022	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	002	8	8/9/2022	COMPETING CONTINUATION	$477,217
2022	2018	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	000	7	6/10/2022	COMPETING CONTINUATION	$0
2022	2018	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	001	7	8/2/2022	COMPETING CONTINUATION	$0
														Subtotal = $477,217

Issue Date FY: 2018 ( Subtotal = $457,636 )
2018	2018	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	001	7	7/20/2018	COMPETING CONTINUATION	$457,636
2018	2018	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	003	7	8/13/2018	COMPETING CONTINUATION	$107,507
2018	2015	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	002	6	8/13/2018	COMPETING CONTINUATION	-$107,507
2018	2015	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	000	6	7/18/2018	COMPETING CONTINUATION	$0
														Subtotal = $457,636

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2011	LEHIGH UNIVERSITY	526 BRODHEAD AVENUE,BLDG #23B	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	000	5	5/3/2016	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $477,949 )
2015	2015	LEHIGH UNIVERSITY	526 BRODHEAD AVENUE,BLDG #23B	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	001	6	8/1/2015	COMPETING CONTINUATION	$477,949
2015	2011	LEHIGH UNIVERSITY	526 BRODHEAD AVENUE,BLDG #23B	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	000	5	5/13/2015	COMPETING CONTINUATION	$0
														Subtotal = $477,949

Issue Date FY: 2011 ( Subtotal = $458,143 )
2011	2011	LEHIGH UNIVERSITY	526 BRODHEAD AVENUE,BLDG #23B	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	001	5	5/25/2011	COMPETING CONTINUATION	$458,143
2011	2007	LEHIGH UNIVERSITY	526 BRODHEAD AVENUE,BLDG #23B	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	000	4	5/24/2011	COMPETING CONTINUATION	$0
														Subtotal = $458,143

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2007	LEHIGH UNIVERSITY	526 BRODHEAD AVENUE,BLDG #23B	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Blood Diseases and Resources Research	000	4	5/20/2010	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2007 ( Subtotal = $233,285 )
2007	2007	LEHIGH UNIVERSITY	526 BRODHEAD AVENUE,BLDG #23B	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Academic Research Enhancement Award	000	4	8/7/2007	COMPETING CONTINUATION	$233,285
														Subtotal = $233,285

Issue Date FY: 2002 ( Subtotal = $145,051 )
2002	2002	LEHIGH UNIVERSITY	526 BRODHEAD AVENUE,BLDG #23B	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Cardiovascular Diseases Research	000	3	7/8/2002	COMPETING CONTINUATION	$145,051
														Subtotal = $145,051

Issue Date FY: 1999 ( Subtotal = $115,125 )
1999	1999	LEHIGH UNIVERSITY	526 BRODHEAD AVENUE,BLDG #23B	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Cardiovascular Diseases Research	000	2	9/17/1999	COMPETING CONTINUATION	$115,125
														Subtotal = $115,125

Grand Total All Awards = $2,364,406

Top

All Categories

About

Search

Reports

Data Submission

Award Information

A Heparin Receptor in Vascular Cells

Award Number: R15HL054269

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/1995

PERIOD OF PERFORMANCE END DATE: 08/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer