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Mechanism-Based Design of Iron-Mediated Carbonyl-Olefin Metathesis Protocols

Award Number: R15GM164970
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Mechanism-Based Design of Iron-Mediated Carbonyl-Olefin Metathesis Protocols - Project Summary The activation of carbonyl-containing substrates by Lewis acids is ever present in organic synthesis. However, Lewis acid-catalyzed carbonyl-olefin ring-closing metathesis exhibits reactivity not typically seen in traditional Lewis acid-mediated systems. Building on our detailed understanding of the catalyst behavior in carbonyl-olefin metathesis, this proposal aims to apply that knowledge to the rational design of new metathesis catalysts. To support this, we will employ synthetic, spectroscopic, kinetic, and computational techniques to explore the chemical space influenced by ligand incorporation, assessing their effects on both the catalytic resting state and the turnover-limiting step. Moreover, the substrate itself is currently the most well-characterized ligand for the catalyst in carbonyl-olefin metathesis. We plan to systematically investigate the role of each component of the metathesis substrates to develop a comprehensive model of substrate behavior. Overall, these in-depth synthetic and mechanistic studies will advance the use of carbonyl-olefin metathesis in the synthesis of medicinally valuable compounds.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $484,636 )
2026	2026	LOYOLA UNIVERSITY OF CHICAGO	820 N MICHIGAN AVE	CHICAGO	IL	60611	COOK	USA	Biomedical Research and Research Training	000	1	5/22/2026	NEW	$484,636
														Subtotal = $484,636

Grand Total All Awards = $484,636

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Mechanism-Based Design of Iron-Mediated Carbonyl-Olefin Metathesis Protocols

Award Number: R15GM164970

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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