Friday, November 22, 2024
11/22/2024
This application is in response to NOSI (NOT-GM-22-017) to acquire a Circular Dichroism Spectropolarimeter as part of an administrative supplement. PI has an active eligible R15 grant (1 R15GM148964-01) with enough remaining time to proceed with a supplement request. Currently, Michigan Tech does not have a CD instrument. Having access to this instrument will greatly enhance PI’s research ability to address specific aim 2 (Characterize physicochemical properties of the diverse protein aggregates) of the funded grant (1 R15GM148964-01). Circular Dichroism can track changes in the secondary structure of proteins undergoing misfolding and aggregation. This technique – in combination with other biophysical and biochemical methods such as chromatography, fluorescence, SEM, AFM, and TEM – will help to better characterize the unique physicochemical properties of the protein aggregates and correlate aggregates’ structure to its associated toxicity.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).
