Thursday, September 18, 2025 9/18/2025

Administrative Supplement for Equipment Purchase

Award Number: R15GM148949
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Administrative Supplement for Equipment Purchase - Project Summary Nuclear RNA processing and surveillance is a complex process involving multiple proteins and protein assemblies that identify and eventually degrade targeted RNA substrates. The RNA helicase, Mtr4, plays a central role in this process by providing a bridge between substrate targeting and RNA decay by the RNA exosome. RNA recognition is performed directly by Mtr4 and by various adaptor proteins that recruit Mtr4 to targeted substrates. A major challenge is to understand the molecular details of how these proteins interact with RNA substrates and with each other to achieve substrate specificity. Additionally, accessory domains within Mtr4 play important but poorly defined roles in substrate recognition and processing. Notably, the available structural data demonstrate that Mtr4 is a highly dynamic protein, but it is not known how protein dynamics relate to helicase function. This project seeks to define the molecular basis for Mtr4 function by employing a variety of biochemical, biophysical and structural approaches, supported by in vivo genetic analyses. The specific aims of this project are to (1) describe the role of Mtr4 accessory domains and (2) characterize interactions within the TRAMP (Trf4-Air2-Mtr4) complex. Undergraduate and graduate researchers with interests in future careers in biomedical research or medicine will be involved in the project.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UTAH STATE UNIVERSITY	1000 OLD MAIN HL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	001	1	9/12/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2022	UTAH STATE UNIVERSITY	1000 OLD MAIN HL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	1	9/12/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $81,627 )
2023	2023	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	1	5/23/2023	SUPPLEMENT FOR EXPANSION	$81,627
														Subtotal = $81,627

Issue Date FY: 2022 ( Subtotal = $430,125 )
2022	2022	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Biomedical Research and Research Training	000	1	9/9/2022	NEW	$430,125
														Subtotal = $430,125

Grand Total All Awards = $511,752

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Administrative Supplement for Equipment Purchase

Award Number: R15GM148949

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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