Tuesday, August 19, 2025 8/19/2025

Charge Transfer Study of DNA/MoS2 interface

Award Number: R15GM147885
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Charge Transfer Study of DNA/MoS2 interface - Project Summary Expansion of tandem DNA repeats cause more than forty genetically transferrable disorders, which affect 4 million people every year. Current state-of-the-art diagnostic technologies for genetic testing for length mutations have their own limitations such as clogging of protein nanopores, requiring labelling steps, frequent false positive/negative results, or short basepair read length. To overcome the limitations that hamper the current biomedical science, there is a critical need to develop new platforms founded on thorough basic science. This AREA proposal involving mainly undergraduate researchers investigates intrinsic character of tandem DNA repeats interfaced with MoS2 surfaces that may manifest into label-free sensing platform for repeat mutations in future. The PI hypothesizes that DNA repeats can produce sequence- and length-dependent charge transfer signals due to the differential affinity of nucleobases for two-dimensional materials, i.e. molybdenum disulfide (MoS2). This is the critical piece of information needed to confirm through a rigorous study. Based on encouraging preliminary results, current project is designed to fundamentally investigate DNA/MoS2 interfaces in detail by electrochemical and surface probe microscopy techniques. In the specific aims, the PI plans to (1) investigate sequence-dependent charge transport at TNR/2D nanomaterials interface, and (2) investigate their behavior with respect to sequence length. The results will also be compared with concentration and conformations effects on the charge transfer character. This AREA proposal will expose the undergraduate researchers to high-quality research in surface chemistry and materials science, which has ultimate application in biomedical research to improve public health. Upon completion, we will be in better position to apply DNA/2D materials for selective and sensitive detection of repeat mutations, which will ultimately improve the lives of millions of individuals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY	900 S NORMAL AVE	CARBONDALE	IL	62901	JACKSON	USA	Biomedical Research and Research Training	000	1	8/15/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $99,660 )
2023	2023	SOUTHERN ILLINOIS UNIVERSITY	900 SOUTH NORMAL AVE	CARBONDALE	IL	62901	JACKSON	USA	Biomedical Research and Research Training	000	1	9/1/2023	SUPPLEMENT FOR EXPANSION	$99,660
														Subtotal = $99,660

Issue Date FY: 2022 ( Subtotal = $429,508 )
2022	2022	SOUTHERN ILLINOIS UNIVERSITY	900 SOUTH NORMAL AVE	CARBONDALE	IL	62901	JACKSON	USA	Biomedical Research and Research Training	000	1	8/29/2022	NEW	$429,508
														Subtotal = $429,508

Grand Total All Awards = $529,168

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Charge Transfer Study of DNA/MoS2 interface

Award Number: R15GM147885

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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