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Engineering hydrophilic/amphiphilic Vitamin B6-based super antioxidant dendrimers for controlling chronic inflammation

Award Number: R15GM147862
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Funds are requested to purchase a new CEM (Discover-2.0) microwave synthesis reactor, which will be installed in the Dow Science building (Dow 345) at Central Michigan University (CMU). Microwave reactors can raise temperatures rapidly by irradiating polar materials in a chemical reaction with microwave energy. In addition to rapid heating, they can carry out chemical reactions under high pressure, enabling the reactions to be heated beyond the boiling point of the solvent being used. Therefore, microwave reactions are much faster compared to thermally heated reactions. Our proposed research is to synthesize and evaluate antioxidant dendrimers formed by joining dendrons with various solubilities to attain solubilities that are biocompatible. All the dendrons and dendrimers involved in this research are designed to produce strong antioxidant activity but no pro-oxidant effects by trapping the transition metal ions within their interior. To attach antioxidant building blocks to a scaffold in our dendron/dendrimer synthesis, we use “alkyne-azide click chemistry”, which requires a copper catalyst. The use of copper ions as catalysts results in severe contamination of our dendrimer with copper ions due to the ability of the dendrimer to chelate copper ions. Therefore, we use copper metal granules instead. Copper metal is a far less efficient catalyst than copper ions, but it does not contaminate our antioxidant products, which is very important. To accelerate the reaction rates, we utilize a microwave reactor with which we can form our target products usually in 10-15 hours (> 1 week without). We have a 14-year-old microwave reactor which fails very frequently due to its deteriorating parts with age. It is difficult to start, and if it starts it only runs for 2-3 hours at a time. Without a microwave, our current grant-funded research will be greatly impacted because long synthesis times will hamper other objectives to be achieved within the proposed time frame. Currently there are no other microwave reactors in the entire CMU community. In summary, (i) availability of a microwave reactor is extremely important for syntheses of our proposed dendrons and dendrimers, which are large and complex molecules and (ii) this supplementary funding will allow us to train undergraduate/graduate research students. We believe that procurement of a state-of-the-art microwave unit with this Administrative Supplement will help accelerate the pace of our proposed research as well as help students acquire useful modern microwave synthesis techniques.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $24,064 )
2024	2024	CENTRAL MICHIGAN UNIVERSITY	119 BOVEE UNIVERSITY CTR	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Biomedical Research and Research Training	000	1	8/27/2024	SUPPLEMENT FOR EXPANSION	$24,064
														Subtotal = $24,064

Issue Date FY: 2023 ( Subtotal = $100,000 )
2023	2023	CENTRAL MICHIGAN UNIVERSITY	119 BOVEE UNIVERSITY CTR	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Biomedical Research and Research Training	000	1	6/12/2023	SUPPLEMENT FOR EXPANSION	$100,000
														Subtotal = $100,000

Issue Date FY: 2022 ( Subtotal = $426,275 )
2022	2022	CENTRAL MICHIGAN UNIVERSITY (INC)	119 BOVEE UNIVERSITY CENTER	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Biomedical Research and Research Training	000	1	8/10/2022	NEW	$426,275
														Subtotal = $426,275

Grand Total All Awards = $550,339

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Engineering hydrophilic/amphiphilic Vitamin B6-based super antioxidant dendrimers for controlling chronic inflammation

Award Number: R15GM147862

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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