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Low-Power Stimulated Raman Time-Lapse Microscope for Tracking Dynamics and Fate of Lipid Droplets in Glioma Cells

Award Number: R15GM140444
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Lipid droplets (LDs) is highly dynamic cellular organelles that play multiple functions in cell lipid metabolism. Reprogramming of lipid metabolism is now considered a hallmark of cancer. LDs accumulate within the cancer cells due to multiple reasons, but the mechanism has not been fully understood. In this project, we will develop new technologies to image the dynamics of LDs in cancer cells. Stimulated Raman scattering (SRS) microscopy is a powerful tool to image label-free LDs in live cells and tissue. However, the laser power used in SRS imaging is too high to conduct long-term time-lapse imaging of live cells. The objective of this AREA project is to establish a low-laser-power time-lapse stimulated Raman microscope and use the imaging platform to depict the dynamics and fate of label-free LDs for understanding their function in glioma progression and their role as a potential therapeutic target. Specific aims include tracking the dynamics and life cycle of lipid droplets formation and degradation in glioma cells and tracking migration and invasion of glioma cells in cultured organotypic mouse brain tissue. The results of this project will advance our understanding on the condition-specific roles of LDs in cancer survival and aggressiveness and will provide new clues to target LDs for potential therapeutic intervention. This AREA project would expose one PhD student and nine undergraduate students to hands on research under the PI’s supervision. Through conducting this project, the research environment at the Binghamton University will be beneficially enhanced in the field of health science and biophotonics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$252 )
2025	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Biomedical Research and Research Training	000	1	12/19/2024	NEW	-$252
														Subtotal = -$252

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Biomedical Research and Research Training	000	1	7/31/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Biomedical Research and Research Training	000	1	6/15/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $433,323 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	Biomedical Research and Research Training	000	1	9/23/2020	NEW	$433,323
														Subtotal = $433,323

Grand Total All Awards = $433,071

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Low-Power Stimulated Raman Time-Lapse Microscope for Tracking Dynamics and Fate of Lipid Droplets in Glioma Cells

Award Number: R15GM140444

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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