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Halogenase Inspired Chemical Catalysis and Methods

Award Number: R15GM139156
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Halogenase Inspired Chemical Catalysis and Methods - Project Summary/Abstract Chiral amino functionalized molecules are common motifs in a variety of bioactive molecules. They are also important chiral building blocks in organic synthesis such as the chiral ligand frameworks that are the pillars in several fields of asymmetric catalysis. The functional importance of these molecules renders their synthesis continuously in high demand. Catalytic processes that can directly utilize abundant chemical feedstocks to achieve the synthesis of these functional molecules are ideal. However, significant challenges remain for the development of such catalytic reactions. The main objective of this program is to develop new classes of catalytic and asymmetric alkene difunctionalizations and other processes that will meet the demands of these challenges and expedite access to chiral amino functionalized motifs. Specifically, this proposal will introduce chiral hypervalent iodine and halonium catalysis as platforms to resolve the regiochemical and enantioselective challenges often encountered in these reactions. Our preliminary data and proposed studies will enable us to: 1) utilize chiral hypervalent iodine catalysis to achieve asymmetric induction for practical olefin oxyamination and explore this class of catalysts as a new element for regiochemical control; and 2) initiate the use of a non- covalent interaction (NCI) – halogen bonding for catalysis development and chemical reaction engineering. Our proposal is innovative based on common and classic intermediates that are comprehensive to undergraduate students to introduce several means of new strategies for regiochemical control and engage an uncommon NCI for catalysis development. These methods use only simple and ubiquitous bifunctional reagents such as amide, urea, carbamate, alcohols, etc as the functionalization reagents. Importantly, our strategy will enable a straightforward route for the asymmetric synthesis of chiral amino functionalized motifs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $456,345 )
2024	2024	UNIVERSITY OF TOLEDO	2801 W BANCROFT ST	TOLEDO	OH	43606	LUCAS	USA	Biomedical Research and Research Training	001	2	8/16/2024	COMPETING CONTINUATION	$458,584
2024	2020	UNIVERSITY OF TOLEDO	2801 W BANCROFT ST	TOLEDO	OH	43606	LUCAS	USA	Biomedical Research and Research Training	000	1	6/3/2024	NEW	-$2,239
														Subtotal = $456,345

Issue Date FY: 2020 ( Subtotal = $451,500 )
2020	2020	UNIVERSITY OF TOLEDO, THE	2801 W BANCROFT ST	TOLEDO	OH	43606	LUCAS	USA	Biomedical Research and Research Training	000	1	8/10/2020	NEW	$451,500
														Subtotal = $451,500

Grand Total All Awards = $907,845

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Halogenase Inspired Chemical Catalysis and Methods

Award Number: R15GM139156

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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