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Targeted ROS releasing PEG-Fibrin composite adhesive-hydrogel to control matrix modulation as a wound healing and tissue engineering support

Award Number: R15GM137298
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY This proposal addresses several existing challenges in developing better control systems for therapeutic tissue engineering including: 1) minimizing infection associated with delivered biomaterials/devices; 2) creating in-situ curable material with a suitable environment for local cell migration, stable cell delivery and promotion of injury repair; 3) establishing a stable adhesive interface between a tissue engineered construct (hydrogel) and injured tissues; 4) targeting spatial and temporal release of multifunctional dose dependent reactive oxygen species (ROS). The ROS releasing composite adhesive-hydrogels and focused ultrasound (FUS) delivery system being developed in this proposal addresses these challenges. The primary innovative component is the possible use of FUS to spatially and temporally target ROS release as a regenerative tissue support that not only aids in stabilizing the matrix metabolic activity of the regenerative site but also provides secondary support through its innate antimicrobial character. The main objectives of this proposal are: 1) create a library of composite hydrogel formulations with controlled ROS release profiles as well as physical and adhesive properties; 2) build a custom FUS therapy system and characterize its ability modulate formulations in real-time to target wound healing and prevent infection in vitro; 3) verify candidate formulations promote wound healing in an Achilles tendon defect model.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Biomedical Research and Research Training	000	1	4/12/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $400,343 )
2020	2020	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Biomedical Research and Research Training	001	1	9/11/2020	NEW	$0
2020	2020	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Biomedical Research and Research Training	000	1	4/9/2020	NEW	$400,343
														Subtotal = $400,343

Grand Total All Awards = $400,343

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Targeted ROS releasing PEG-Fibrin composite adhesive-hydrogel to control matrix modulation as a wound healing and tissue engineering support

Award Number: R15GM137298

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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