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Establishing the scaffolding role of the TON1A protein in the formation of a noncentrosomal microtubule cortical array

Award Number: R15GM137247
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2024

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Establishing the scaffolding role of the TON1A protein in the formation of a noncentrosomal microtubule cortical array - Organized microtubule arrays are essential for cell division, cell migration, trafficking, and cell morphogenesis. Proliferating and migrating animal cells feature radial arrays of centrosome-anchored microtubules, whereas differentiated animal cells and all plant cells can organize their microtubules without centrosomes. These noncentrosomal microtubule arrays are involved in vital cellular functions, however the mechanisms involved in microtubule organization in the absence of centrosomes are not well understood. Consistent with the essential functions of organized microtubule arrays, plant and animal cells widely utilize evolutionarily conserved molecules to regulate microtubule organization. A ring-like microtubule array is organized at the cortex of plant cells entering mitosis. This microtubule array, the preprophase band (PPB), is important for spindle guidance and positioning of the cell division plane. A complex of evolutionarily conserved proteins that include TON1 and TRM proteins, which are homologous to the human microtubule-anchoring centrosomal proteins FOP and CAP350, and the protein phosphatase PP2A drives the organization of the PPB. The function of TON1 proteins in the complex of TON1/TRM/Ton2/PP2a proteins promoting PPB array formation will be tested. Understanding the mechanism of PPB microtubule array organization will uncover common mechanisms and specific modifications driving the formation of centrosomal and noncentrosomal arrays.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$4,725 )
2024	2020	BOARD OF TRUSTEES OF ILLINOIS STATE UNIVERSITY	CAMPUS BOX 1100	NORMAL	IL	61790	MCLEAN	USA	Biomedical Research and Research Training	000	1	9/25/2024	NEW	-$4,725
														Subtotal = -$4,725

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	BOARD OF TRUSTEES OF ILLINOIS STATE UNIVERSITY	302 HOVEY HALL	NORMAL	IL	61790	MCLEAN	USA	Biomedical Research and Research Training	000	1	3/30/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $369,375 )
2020	2020	BOARD OF TRUSTEES OF ILLINOIS STATE UNIVERSITY	302 HOVEY HALL	NORMAL	IL	61790	MCLEAN	USA	Biomedical Research and Research Training	000	1	2/19/2020	NEW	$369,375
														Subtotal = $369,375

Grand Total All Awards = $364,650

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Establishing the scaffolding role of the TON1A protein in the formation of a noncentrosomal microtubule cortical array

Award Number: R15GM137247

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2024

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