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The role of CTCF in establishing and maintaining chromatin architecture during M. musculus spermatogenesis

Award Number: R15GM135793
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Title: AREA R15 application - The role of CTCF in establishing and maintaining chromatin architecture during M. musculus spermatogenesis With the completion of the Human Genome Project in 2003 and the 1000 Genomes Project in 2012, scientists have gained deep understanding of the genetic variation within the human genome, yet with the recent discovery of the inheritance of acquired states (transgenerational inheritance), our understanding of the way in which traits can be passed from parent to offspring has dramatically changed. Though the study of transgenerational inheritance has recently pushed many exciting new boundaries, fundamental questions remain about the more basic functional roles of underlying epigenetic mechanisms. In order for epigenetic patterns to pass from parent to offspring, epigenetic marks must be established during gametogenesis and transmitted to offspring. One of the most widely studied epigenetic marks is chromatin organization yet despite a recent interest in the specialized chromatin patterning exhibited in mammalian gametes, the functional consequence of these patterns remains unknown. Using a specialized suite of molecular tools unique to our laboratory, the study proposed here will focus on the link between the essential DNA binding factor CTCF and the unique chromatin architecture established during spermatogenesis in M. musculus. In line with the goals of the NIH AREA research grant program, students performing the research funded by this proposal at Rowan University will be directly involved in cutting edge molecular biology research techniques while at the same time working on a hypothesis-driven project which has the potential to significantly affect the way in which we approach epigenetic inheritance. The completion of this research project at Rowan will continue to push forward our mission of addressing paradigm-shifting scientific problems while providing students with the best possible avenue to engage in the latest scientific practices to develop highly-trained contributors to the scientific community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$110,536 )
2024	2019	ROWAN UNIVERSITY	201 MULLICA HILL RD	GLASSBORO	NJ	08028	GLOUCESTER	USA	Biomedical Research and Research Training	000	1	1/8/2024	NEW	-$110,536
														Subtotal = -$110,536

Issue Date FY: 2019 ( Subtotal = $445,637 )
2019	2019	ROWAN UNIVERSITY	201 MULLICA HILL RD RT 322	GLASSBORO	NJ	08028	GLOUCESTER	USA	Biomedical Research and Research Training	000	1	9/19/2019	NEW	$445,637
														Subtotal = $445,637

Grand Total All Awards = $335,101

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The role of CTCF in establishing and maintaining chromatin architecture during M. musculus spermatogenesis

Award Number: R15GM135793

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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