Monday, November 25, 2024
11/25/2024
In principle, highly fluorescent rhodopsins could be employed as voltage sensors in neuroscience imaging. However, rhodopsin mutants featuring a fluorescence efficiency close to the one of the green fluorescence protein have not been discovered yet. Most importantly, we lack the molecular-level understanding required to predict if and how a specific set of mutations can amplify the weak fluorescence of the rhodopsin chromophore. We propose to exploit state-of-the-art quantum chemical methods to systematically investigate these issues and to reengineer a microbial rhodopsin into a highly sensitive, genetically encodable, optogenetic tool for action potential visualization. -1-
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