Tuesday, July 1, 2025 7/1/2025

Roadmap for Intestinal Regeneration

Award Number: R15GM124595
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2017
PERIOD OF PERFORMANCE END DATE: 08/31/2025

Group Awards By:

View Award Description

Roadmap for Intestinal Regeneration - SUMMARY Digestive diseases affect millions of Americans each year, and a significant number will die from them. The main culprits of these diseases are disrupted cellular mechanisms for homeostatic control and deficient repair mechanisms. Repair mechanisms play an important role in healing after natural events that damage the digestive tract and after gastrointestinal surgery. Accordingly, the ability to regenerate intestinal tissue could be an important therapeutic tool. Although advances have been made on the regeneration of the luminal layer of the vertebrate digestive tract, little is known about the regeneration of other cells and tissue layers or of the organ as a whole. Part of the problem is that in vertebrates, these cells or tissue layers have limited regenerative capacity. This proposal uses a novel model system, an echinoderm, to study intestinal regeneration. Among deuterostomes, echinoderms comprise some of the closest relative to vertebrates that have amazing regenerative capacities. One of these organisms, the sea cucumber Holothuria glaberrima, possesses the innate ability to regenerate their entire digestive tract after it is self- autotomized. The present proposal searches to establish the role of cellular mechanisms and their underlying molecular bases on the regeneration of H. glaberrima intestine. Signaling pathways and candidate transcription factor genes will be probed pharmacologically and by gene knockdown, in vivo and in vitro, to determine their involvement in intestinal regeneration. The obtained data will be incorporated into our gene/cellular network that explains the step-by-step activation of cellular events. Additional experiments will define the cellular populations found in normal and regenerating intestines. These experiments will serve to further identify the cells/genes associated with the early regenerative events in intestinal regeneration. Our results could serve as the basis for the development of new therapeutics/drugs that modulate regenerative processes. They will also provide important information to other fields of research, including wound healing, immunology, cell biology, genomics and phylogenetics. Finally, the outcome of these experiments will bring us closer to a better understanding of regenerative processes in general.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$521 )
2023	2022	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	000	2	10/1/2022	COMPETING CONTINUATION	-$521
														Subtotal = -$521

Issue Date FY: 2022 ( Subtotal = $441,602 )
2022	2022	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	001	2	9/22/2022	COMPETING CONTINUATION	$447,000
2022	2022	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	004	2	9/29/2022	COMPETING CONTINUATION	$521
2022	2019	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	002	1	9/26/2022	SUPPLEMENT FOR EXPANSION	-$5,398
2022	2017	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	000	1	3/2/2022	NEW	$0
2022	2017	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	003	1	9/29/2022	NEW	-$521
														Subtotal = $441,602

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2017	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	001	1	5/21/2021	NEW	$0
2021	2017	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	000	1	5/19/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $200,943 )
2019	2019	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	000	1	5/2/2019	SUPPLEMENT FOR EXPANSION	$200,943
														Subtotal = $200,943

Issue Date FY: 2017 ( Subtotal = $447,000 )
2017	2017	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	000	1	6/23/2017	NEW	$447,000
														Subtotal = $447,000

Grand Total All Awards = $1,089,024

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Roadmap for Intestinal Regeneration

Award Number: R15GM124595

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2017

PERIOD OF PERFORMANCE END DATE: 08/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer