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Quantitative AFM Investigations of Adhesion of a Planktonic Bacterial Predator to Biofilm Prey

Award Number: R15GM120665
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2022

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Quantitative AFM Investigations of Adhesion of a Planktonic Bacterial Predator to Biofilm Prey - Project Summary Bacteria colonize surfaces, including the tissues of the human body, as complex and structured communities called biofilms. As a result, bacterial biofilms influence human health. Some biofilms are pathogenic, and because the bacteria in biofilms can be phenotypically and metabolically distinct from their planktonic, free-swimming cousins, they can be difficult to control or eradicate using conventional means. As a result, persistent chronic infection from biofilms represents a serious problem that characterizes about two-thirds of infections treated by physicians in the developed world (Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: A common cause of persistent infections. Science. 1999;284:1318–1322). The bacterial predator Bdellovibrio bacteriovorus has been shown to consume bacterial biofilms robustly, and thus holds promise as a potential biofilm control agent. However, it is critical to understand at the molecular level how the predator differentiates between prey and non-prey cells. Since B. bacteriovorus is harmless to eukaryotes and is member of the human microbiome, both the specific and general biochemical knowledge produced by these experiments may lead to new, innovative means to control Gram-negative bacterial biofilms. The proposed experiments use model organisms that are nonpathogenic but that have close relatives that cause human pathogenicity. Moreover, given that no conferred genetic resistance to B. bacteriovorus has been found in the 53 years since the first published paper on this bacterial predator, drug- resistant and pathogenic strains affecting human health (e.g., contaminated joint implants, biofilms in the lungs of cystic fibrosis patients, skin infections) are among the most relevant applications of the proposed research findings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$9,004 )
2023	2016	OCCIDENTAL COLLEGE	1600 CAMPUS RD	LOS ANGELES	CA	90041	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	10/1/2022	NEW	-$9,004
														Subtotal = -$9,004

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2016	OCCIDENTAL COLLEGE	1600 CAMPUS RD	LOS ANGELES	CA	90041	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	11/16/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2016	OCCIDENTAL COLLEGE	1600 CAMPUS RD	LOS ANGELES	CA	90041	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	3/10/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2016	OCCIDENTAL COLLEGE	1600 CAMPUS RD	LOS ANGELES	CA	90041	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	6/23/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $391,433 )
2016	2016	OCCIDENTAL COLLEGE	1600 CAMPUS ROAD	LOS ANGELES	CA	90041	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	7/28/2016	NEW	$391,433
														Subtotal = $391,433

Grand Total All Awards = $382,429

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Quantitative AFM Investigations of Adhesion of a Planktonic Bacterial Predator to Biofilm Prey

Award Number: R15GM120665

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2022

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