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Methodology for the Synthesis of Structurally Homogeneous N-Linked Glycopeptides

Award Number: R15GM109839
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2015
PERIOD OF PERFORMANCE END DATE: 08/31/2019

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Methodology for the Synthesis of Structurally Homogeneous N-Linked Glycopeptides - DESCRIPTION (provided by applicant): This project involves the development of methodologies that provide convenient access to homogeneous glycoproteins. Specifically, the PI and his undergraduate research team at Seattle University (SU) will develop a novel, efficient de novo synthesis of N-linked glycopeptides that employs ß-glycosylhydrazides, generated via hydrazide glycosylation, as ß-glycosylamine surrogates. The proposed method to synthesize N-linked glycopeptides will harness hydrazide glycosylation reactions to provide glycopeptides with natural glycosidic linkages and with greater efficiency than traditional methods. Current oxyamine and hydrazide glycosylation methods produce glycoproteins with non-natural N-linked glycoproteins containing oxime, oxyamine, or hydrazine glycan-peptide linkages and thus current methods make it difficult for chemists and biologists to study with confidence the influence of glycan structure on protein function. The PI chose to pursue his independent career at SU, a predominantly undergraduate institution, so that his research program could simultaneously impact the scientific community and transform the lives of undergraduate students. All of the research the PI has performed since he began his career at SU in 2005 has been done in collaboration with undergraduate research students; undergraduate students will work side-by-side with the PI on all aspects of the work proposed here.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = -$1,224 )
2020	2015	SEATTLE UNIVERSITY	901 12TH AVE	SEATTLE	WA	98122	KING	USA	Biomedical Research and Research Training	000	1	11/4/2019	NEW	-$1,224
														Subtotal = -$1,224

Issue Date FY: 2015 ( Subtotal = $231,054 )
2015	2015	SEATTLE UNIVERSITY	BROADWAY AND MADISON	SEATTLE	WA	98122	KING	USA	Biomedical Research and Research Training	000	1	8/10/2015	NEW	$231,054
														Subtotal = $231,054

Grand Total All Awards = $229,830

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Methodology for the Synthesis of Structurally Homogeneous N-Linked Glycopeptides

Award Number: R15GM109839

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2015

PERIOD OF PERFORMANCE END DATE: 08/31/2019

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